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Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development.

Nat. Immunol.2003 Nov;4(11):1136-43. Epub 2003 Sep 28
Valérie Pouillon 1 , Romana Hascakova-Bartova , Bernard Pajak , Emmanuelle Adam , Françoise Bex , Valérie Dewaste , Carine Van Lint , Oberdan Leo , Christophe Erneux , Stéphane Schurmans
Valérie Pouillon 1 , Romana Hascakova-Bartova , Bernard Pajak , Emmanuelle Adam , Françoise Bex , Valérie Dewaste , Carine Van Lint , Oberdan Leo , Christophe Erneux , Stéphane Schurmans
+ et al

[No authors listed]

Author information
  • 1 IRIBHM, IBMM, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.

摘要


Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development.