Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer.
[No authors listed]
摘要
Loss of heterozygosity (LOH) on chromosome arm 9q is the most frequent genetic alteration found in superficial and invasive transitional cell carcinoma (TCC) in a previous microsatellite-based deletion mapping study of the bladder and upper urinary tract, indicating the presence of one or more important tumor suppressor genes (TSGs). One of the putative tumor suppressor loci on 9q (DBC1) was mapped to 9q32-33 and the candidate region was localized within a single YAC. We report here a case of superficial papillary TCC, which showed a homozygous deletion encompassing this candidate tumor suppressor region. The region of homozygous deletion spanned the interval between D9S275 and AFMA239XA9 at 9q32-33, and was estimated to be The paired, self-replicating genetic structures of cells that contain the cellular DNA; the nucleotide sequence of the DNA encodes the linear array of genes.
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基因功能
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原始数据
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文献解读
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