| Type | Description |
|---|---|
| Definition | potassium voltage-gated channel subfamily E regulatory subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:39:00 | An arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2. | 31679457 |
| 2020-07-04 10:54:00 | KCNE2 rs8134775 was associated with a decreased atrial fibrillation (AF) risk in the Chinese Han population in the allele model. Minor allele T of GJA5 rs35594137 was associated with a decreased AF risk, and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive models. Results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF in the Chinese Han population. | 31270966 |
| 2020-05-30 10:10:00 | In vitro functional assays showed miR-584-5p depletion decreased HCC cell proliferation, cell migration, and cell invasion. Moreover, miR-584-5p functions by directly targeting KCNE2, and it in turn, mediates the effects of miR-584-5p on HCC cell behaviors. | 31044566 |
| 2017-09-23 13:29:00 | On the basis of clinical phenotype, the high allelic frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous documentation of genotype-phenotype segregation, our findings suggest that many KCNE2 variants, and perhaps all, have been erroneously designated as LQTS-causative mutations. Instead, KCNE2 variants may confer proarrhythmic susceptibility when provoked by additional envir | 28794082 |
| 2017-09-16 12:01:00 | These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM. | 28280005 |
| Type | IDs |
|---|---|
| Synonymous | ATFB4, LQT5, LQT6, MIRP1 |
| Gene |
UniProtKB-ID:
KCNE2_HUMAN
UniprotKB:
Q9Y6J6
UniParc:
UPI000004A1D8
EMBL:
CH471079,
BC112087,
AF302095,
BC093892,
DQ784804,
AF071002
Ensembl:
ENSG00000159197
KO:
hsa:9992
|
| Nucleutide sequences |
EMBL-CDS:
AAD28086.1,
AAG13416.1,
ABQ01239.1,
AAI12088.1,
AAH93892.1,
EAX09791.1
Ensembl_TRS:
ENST00000290310
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000290310
RefSeq:
NP_751951.1
|
| Others |
UniRef100:
UniRef100_Q9Y6J6
UniRef90:
UniRef90_Q9Y6J6
UniRef50:
UniRef50_Q9Y6J6
UniGene:
Hs.551521,
Hs.736062
CCDS:
CCDS13635.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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