| Type | Description |
|---|---|
| Definition | REC8 meiotic recombination protein |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:28:00 | REC8 suppresses tumor angiogenesis by inhibition of NF-kappaB-mediated vascular endothelial growth factor expression in gastric cancer cells. | 32958054 |
| 2019-12-07 11:45:00 | Rec8-Stag3 cohesin is shown to be susceptible to Wapl-dependent ring opening and sororin-mediated protection. | 29724914 |
| 2018-08-25 10:48:00 | we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer. | 29393474 |
| 2017-09-02 12:51:00 | Study confirmed that REC8 was downregulated in gastric neoplasm, especially in the EBV-associated subtype, via promoter methylation. | 27212034 |
| 2016-12-17 10:59:00 | REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K pathway may represent an important mechanism mediating the oncogenic functions of the PI3K pathway | 26472282 |
| Type | IDs |
|---|---|
| Synonymous | HR21spB, REC8L1, Rec8p |
| Gene |
UniProtKB-ID:
REC8_HUMAN
UniprotKB:
O95072
UniParc:
UPI000044030C,
UPI00000700FD
EMBL:
CH471078,
AK001435,
AL832973,
BC019326,
BC004159,
AK291191,
CR457263,
AL136295,
AF006264,
BC010887
Ensembl:
ENSG00000285007,
ENSG00000100918
KO:
hsa:9985
|
| Nucleutide sequences |
EMBL-CDS:
EAW66089.1,
AAH19326.1,
EAW66090.1,
CAH56339.1,
CAG33544.1,
AAH04159.1,
BAF83880.1,
AAD01193.1,
AAH10887.1,
BAA91690.1
Ensembl_TRS:
ENST00000620473,
ENST00000611366,
ENST00000646765,
ENST00000642486
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000495458,
ENSP00000482439,
ENSP00000493523,
ENSP00000482546
RefSeq:
XP_016877330.1,
NP_005123.2,
NP_001041670.1,
XP_024305563.1,
XP_011535723.1,
XP_024305562.1,
XP_024305560.1,
XP_024305564.1,
XP_024305561.1
|
| Others |
UniRef100:
UniRef100_O95072
UniRef90:
UniRef90_O95072
UniRef50:
UniRef50_O95072
UniGene:
Hs.419259
CCDS:
CCDS41932.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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