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9973 CCS

9973

CCS

copper chaperone for superoxide dismutase

protein-coding

Homo sapiens

基因描述

Type Description
Definition copper chaperone for superoxide dismutase

研究结论

Date Results Publications
2020-12-05 12:57:00 Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). 32121118
2020-03-28 11:33:00 Here, we show that DCAC50, a recently developed small-molecule inhibitor of the intracellular copper chaperones, ATOX1 and CCS, reduces cell proliferation and elevates oxidative stress, triggering apoptosis in a panel of triple-negative breast cancer (TNBC) cells. 30824611
2019-11-30 12:38:00 Molecular recognition and maturation of SOD1 by its evolutionarily destabilized cognate chaperone CCS has been reported. 30735496
2019-08-03 12:46:00 CCS-D2 forms a stable complex with zinc-bound SOD1 in human cells, that has a twofold stabilizing effect: it both prevents the accumulation of unstructured mutant SOD1 and promotes zinc binding. CCS-D2 interacts with apo-SOD1 in vitro, suggesting that in cells CCS stabilizes mutant apo-SOD1 prior to zinc binding. 29234142
2016-10-22 12:32:00 In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] 26745464

名称对应

Type IDs
Gene
UniProtKB-ID: CCS_HUMAN
UniprotKB: O14618
UniParc: UPI0000127323
EMBL: AF002210, CR541928, BC112055, AY113179, BC105016
Ensembl: ENSG00000173992
KO: hsa:9973
Nucleutide sequences
EMBL-CDS: AAI12056.1, AAC51764.1, AAI05017.1, AAM50090.1, CAG46726.1
Ensembl_TRS: ENST00000533244
Protein sequencees
Ensembl_PRO: ENSP00000436318
RefSeq: NP_005116.1
Others
UniRef100: UniRef100_O14618
UniRef90: UniRef90_O14618
UniRef50: UniRef50_O14618
UniGene: Hs.502917
CCDS: CCDS8146.1

全选

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