Type | Description |
---|---|
Definition | copper chaperone for superoxide dismutase |
Date | Results | Publications |
---|---|---|
2020-12-05 12:57:00 | Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). | 32121118 |
2020-03-28 11:33:00 | Here, we show that DCAC50, a recently developed small-molecule inhibitor of the intracellular copper chaperones, ATOX1 and CCS, reduces cell proliferation and elevates oxidative stress, triggering apoptosis in a panel of triple-negative breast cancer (TNBC) cells. | 30824611 |
2019-11-30 12:38:00 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilized cognate chaperone CCS has been reported. | 30735496 |
2019-08-03 12:46:00 | CCS-D2 forms a stable complex with zinc-bound SOD1 in human cells, that has a twofold stabilizing effect: it both prevents the accumulation of unstructured mutant SOD1 and promotes zinc binding. CCS-D2 interacts with apo-SOD1 in vitro, suggesting that in cells CCS stabilizes mutant apo-SOD1 prior to zinc binding. | 29234142 |
2016-10-22 12:32:00 | In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] | 26745464 |
Type | IDs |
---|---|
Gene |
UniProtKB-ID:
CCS_HUMAN
UniprotKB:
O14618
UniParc:
UPI0000127323
EMBL:
AF002210,
CR541928,
BC112055,
AY113179,
BC105016
Ensembl:
ENSG00000173992
KO:
hsa:9973
|
Nucleutide sequences |
EMBL-CDS:
AAI12056.1,
AAC51764.1,
AAI05017.1,
AAM50090.1,
CAG46726.1
Ensembl_TRS:
ENST00000533244
|
Protein sequencees |
Ensembl_PRO:
ENSP00000436318
RefSeq:
NP_005116.1
|
Others |
UniRef100:
UniRef100_O14618
UniRef90:
UniRef90_O14618
UniRef50:
UniRef50_O14618
UniGene:
Hs.502917
CCDS:
CCDS8146.1
|
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