| Type | Description |
|---|---|
| Definition | cell division cycle 34 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:26:00 | Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy. | 32268269 |
| 2020-12-19 13:42:00 | Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis. | 32114396 |
| 2020-06-13 10:32:00 | UBE2R2 alone had negligible ubiquitylation activity at physiological concentrations and the ablation of UBE2R1/2 had no effect on the stability of SCF substrates in cells. A genome-wide CRISPR screen revealed that an additional E2 enzyme, UBE2G1, buffers against the loss of UBE2R1/2. | 31868589 |
| 2018-11-03 10:52:00 | study finds that mutation of the catalytically active cysteine to serine (C93S) results in the reduced ubiquitination, increased stability, and attenuated degradation rate of CDC34; Through semi-quantitative proteomics, identified the CDC34-interacting proteins and discovered that the wild-type and mutant proteins have many differentially interacted proteins | 29564676 |
| 2017-05-27 11:50:00 | Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis. | 27044868 |
| Type | IDs |
|---|---|
| Synonymous | E2-CDC34, UBC3, UBCH3, UBE2R1 |
| Gene |
UniProtKB-ID:
UB2R1_HUMAN,
A0A024R1Z1_HUMAN
UniprotKB:
P49427,
A0A024R1Z1
UniParc:
UPI000013795A
EMBL:
L22005,
AK291554,
BT006659,
BC018143,
BC009850,
BC023979,
AY650399,
CH471242
Ensembl:
ENSG00000099804
KO:
hsa:997
|
| Nucleutide sequences |
EMBL-CDS:
AAT46688.1,
AAH09850.1,
AAH23979.1,
AAP35305.1,
AAC37534.1,
BAF84243.1,
AAH18143.1,
EAW61190.1,
EAW61191.1
Gene_ORFName:
hCG_20568
Ensembl_TRS:
ENST00000215574
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000215574
RefSeq:
NP_004350.1,
XP_006723015.1,
XP_005259747.1
|
| Others |
UniRef100:
UniRef100_P49427
UniRef90:
UniRef90_P49427
UniRef50:
UniRef50_P49427
UniGene:
Hs.514997
CCDS:
CCDS12030.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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