| Type | Description |
|---|---|
| Definition | SMG7 nonsense mediated mRNA decay factor |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:14:00 | Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1. | 31511540 |
| 2019-09-07 11:10:00 | in gastric and colorectal cancers, study found SMG7 somatic mutations, which consisted of frameshift mutations by a deletion (c.2454delA (p. Met849fsx1) and a duplication (c.2545dupA (p. Met849Asnfsx10)) within the repeat | 27771886 |
| 2017-09-23 13:53:00 | Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. | 28461625 |
| 2017-09-09 11:53:00 | Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. | 27864472 |
| 2017-05-27 11:55:00 | We showed SMG7 mRNA levels in peripheral blood mononuclear cells correlated inversely with antinuclear antibody titres of patients with systemic lupus erythematosus. The inverse relationship between levels of the risk allele-associated SMG7 mRNAs and antinuclear antibody suggested the novel contribution of mRNA surveillance pathway to systemic lupus erythematosus pathogenesis. | 26783109 |
| Type | IDs |
|---|---|
| Synonymous | C1orf16, EST1C, SGA56M |
| Gene |
UniProtKB-ID:
SMG7_HUMAN,
E9PD50_HUMAN,
Q6TV06_HUMAN
UniprotKB:
Q92540,
E9PD50,
Q6TV06
UniParc:
UPI0000203D1B,
UPI00002520C8,
UPI0000D6205B,
UPI0000253839,
UPI0001E8F53E,
UPI0001AE796F
EMBL:
AL359876,
AL449223,
BC052565,
D87437,
AK299178,
AL137800,
AB085674,
BC036381,
AY386363,
AL355387,
CH471067
Ensembl:
ENSG00000116698
KO:
hsa:9887
|
| Nucleutide sequences |
EMBL-CDS:
BAA13381.2,
AAH36381.1,
BAG61224.1,
BAC53621.1,
AAH52565.1,
EAW91154.1,
EAW91158.1,
AAR25620.1
Gene_ORFName:
hCG_39862
Ensembl_TRS:
ENST00000515829,
ENST00000508461,
ENST00000347615,
ENST00000507469,
ENST00000367537
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000425133,
ENSP00000421358,
ENSP00000426915,
ENSP00000340766,
ENSP00000356507
RefSeq:
XP_011508508.1,
NP_001337148.1,
NP_001167532.1,
XP_005245706.1,
XP_016858457.1,
XP_011508509.1,
NP_001362513.1,
NP_001337149.1,
XP_011508511.1,
XP_016858459.1,
NP_001337150.1,
NP_963863.2,
XP_011508512.1,
NP_001337151.1,
NP_001362514.1,
NP_001317936.1,
XP_011508510.1,
XP_011508507.1,
NP_775179.1,
XP_016858458.1,
XP_005245710.1,
NP_963862.1
|
| Others |
UniRef100:
UniRef100_Q6TV06,
UniRef100_E9PD50,
UniRef100_Q92540
UniRef90:
UniRef90_Q92540,
UniRef90_G3QIU3
UniRef50:
UniRef50_Q92540
UniGene:
Hs.591463
CCDS:
CCDS1355.1,
CCDS53445.1,
CCDS53444.1,
CCDS41445.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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