| Type | Description |
|---|---|
| Definition | FCH and double SH3 domains 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:49:00 | FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking. | 32678845 |
| 2018-11-10 10:17:00 | Loss of FCHSD2 activity in nonsmall cell lung cancer (NSCLC) cells leads to increased cell-surface expression and altered signaling downstream of EGFR, resulting in enhanced cell proliferation and migration. | 30249660 |
| 2018-01-06 12:50:00 | Established 3 models of Carom-receptor complexes and their intracellular trafficking based on protein interaction and subcellular localization. Carom may mediate receptor endocytosis and transport endocytic receptors to the cytoplasm for receptor signaling and lysosome/proteasome degradation. Review. | 28199211 |
| 2017-07-08 10:15:00 | A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. | 26663301 |
| 2012-12-08 11:21:00 | our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for Acute myeloid leukemia patients | 22902056 |
| Type | IDs |
|---|---|
| Synonymous | NWK, NWK1, SH3MD3 |
| Gene |
UniProtKB-ID:
FCSD2_HUMAN
UniprotKB:
O94868
UniParc:
UPI0000251F08,
UPI0000073319,
UPI0000072422
EMBL:
AP004241,
BC010394,
AK297928,
AP002455,
AL133567,
AB018312,
BC017751,
AP002381
Ensembl:
ENSG00000137478
KO:
hsa:9873
|
| Nucleutide sequences |
EMBL-CDS:
CAB63720.1,
AAH10394.1,
BAG60245.1,
AAH17751.1,
BAA34489.2
Ensembl_TRS:
ENST00000409418,
ENST00000311172,
ENST00000409853
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000386314,
ENSP00000308978,
ENSP00000386722
RefSeq:
XP_011543711.1,
NP_055639.2,
XP_011543712.1,
XP_016874121.1
|
| Others |
UniRef100:
UniRef100_O94868
UniRef90:
UniRef90_O94868
UniRef50:
UniRef50_O94868
UniGene:
Hs.744959
CCDS:
CCDS8218.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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