| Type | Description |
|---|---|
| Definition | retinol dehydrogenase 10 (all-trans) |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 14:06:00 | Embryos with deficient retinoid signaling were generated by stage-specific inactivation of retinol dehydrogenase 10 (Rdh10), a gene crucial for the production of RA during embryogenesis. The finding that cleft palate in retinoid deficiency results from a lack of fetal mouth movement might help elucidate cleft palate etiology and improve early diagnosis in human disorders involving defects of pharyngeal development | 31300413 |
| 2018-12-22 11:34:00 | 11-cis-retinol is oxidized selectively in cones to the 11-cis-retinal used for pigment regeneration; RDH10 is not the enzyme responsible for this oxidation. | 28539612 |
| 2018-09-01 11:29:00 | RDH10 and Retinoic acid are required for salivary gland initiation. | 29986869 |
| 2018-06-02 10:30:00 | Embryonic fibroblasts from Rdh10 heterozygote hypomorphs or with a total Rdh10 knockout exhibit decreased all-trans-retinoic acid biosynthesis and escalated adipogenesis. | 29321172 |
| 2017-05-27 10:48:00 | Rdh10 null mutant mouse embryos exhibited dorsal pancreas agenesis and a hypoplastic ventral pancreas with retarded tubulogenesis and branching. Conditional disruption of Rdh10 from the endoderm caused increased mortality, reduced body weight, and lowered blood glucose levels after birth. Endodermal Rdh10 deficiency led to a smaller dorsal pancreas with a reduced density of early glucagon(+) and insulin(+) cells. | 27740873 |
| Type | IDs |
|---|---|
| Synonymous | 3110069K09Rik, 4921506A21Rik, AI875664, AW549993, D1Ertd762e, m366Asp |
| Gene |
UniProtKB-ID:
RDH10_MOUSE
UniprotKB:
Q8VCH7
UniParc:
UPI00000E8BA4
EMBL:
AF456767,
BC019796
Ensembl:
ENSMUSG00000025921
KO:
mmu:98711
|
| Nucleutide sequences |
EMBL-CDS:
AAN64749.1,
AAH19796.2
Ensembl_TRS:
ENSMUST00000027053
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027053
RefSeq:
NP_598593.1
|
| Others |
UniRef100:
UniRef100_Q8VCH7
UniRef90:
UniRef90_Q8VCH7
UniRef50:
UniRef50_Q8VCH7
UniGene:
Mm.274376
CCDS:
CCDS14830.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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