| Type | Description |
|---|---|
| Definition | apoptosis resistant E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:58:00 | Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients. | 32151281 |
| 2020-06-27 11:26:00 | The AREL1 HECT domain assembled Lys(33)-, Lys(48)-, and Lys(63)-linked polyubiquitin chains. E701A substitution in the AREL1 HECT domain substantially increased its autopolyubiquitination and SMAC ubiquitination activity, whereas deletion of the last three amino acids at the C terminus completely abrogated AREL1 autoubiquitination and reduced SMAC ubiquitination. | 31732561 |
| 2017-07-22 11:30:00 | new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4. | 27162139 |
| 2010-06-30 22:07:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | FIEL1, KIAA0317 |
| Gene |
UniProtKB-ID:
AREL1_HUMAN
UniprotKB:
O15033
UniParc:
UPI0000073D44,
UPI000049DDBD
EMBL:
AB002315,
AC007956,
BC032944,
CH471061,
AK304217
Ensembl:
ENSG00000119682
KO:
hsa:9870
|
| Nucleutide sequences |
EMBL-CDS:
AAF61276.1,
BAA20775.2,
AAH32944.1,
EAW81186.1,
BAG65089.1
Ensembl_TRS:
ENST00000356357
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348714
RefSeq:
XP_011535718.1,
XP_011535717.1,
XP_005268301.1,
XP_006720407.1,
XP_011535719.1,
NP_001034568.1
|
| Others |
UniRef100:
UniRef100_O15033
UniRef90:
UniRef90_O15033
UniRef50:
UniRef50_O15033
UniGene:
Hs.497417
CCDS:
CCDS41971.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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