| Type | Description |
|---|---|
| Definition | tripartite motif containing 66 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 11:59:00 | The miR-451a targets tripartite motif-containing 66 may provide novel therapeutic targets for the treatment of osteosarcoma. | 31434545 |
| 2020-01-11 11:36:00 | TRIM66 recruits Sirt6 to deacetylate H3K56ac, negatively regulating the level of H3K56ac and facilitating the initiation of DNA damage repair. Importantly, Trim66-deficient blastocysts also exhibit higher levels of H3K56ac and DNA damage. | 31537782 |
| 2019-11-09 13:06:00 | High TRIM66 expression is associated with cell proliferation, migration and invasion in colorectal cancer through pathway. | 31472144 |
| 2019-08-10 12:37:00 | TRIM66 functioned as an oncogenic protein in HCC by promoting the activation of Wnt/beta-catenin signaling | 30710548 |
| 2018-11-10 11:58:00 | Silence TRIM66 expression suppressed non-small cell lung cancer cell proliferation, invasion, and migration | 29929749 |
| Type | IDs |
|---|---|
| Synonymous | C11orf29, TIF1D, TIF1DELTA |
| Gene |
UniProtKB-ID:
TRI66_HUMAN,
A0A2R8YEA1_HUMAN
UniprotKB:
O15016,
A0A2R8YEA1
UniParc:
UPI000006F65B,
UPI0001837E9D,
UPI0003EAF72F
EMBL:
AC104360,
AC091053,
AB002296,
AJ400879
Ensembl:
ENSG00000166436
KO:
hsa:9866
|
| Nucleutide sequences |
EMBL-CDS:
CAC35389.1,
BAA20758.2
Ensembl_TRS:
ENST00000299550,
ENST00000646038
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000299550,
ENSP00000495413
RefSeq:
XP_011518814.1,
XP_011518816.1,
XP_011518827.1,
XP_011518812.1,
XP_011518821.1,
XP_011518829.1,
XP_011518826.1,
XP_011518810.1,
XP_016874120.1,
NP_001374952.1,
NP_001374953.1,
XP_011518825.1,
XP_011518828.1,
XP_016874118.1,
XP_011518817.1,
NP_055633.1,
XP_011518820.1,
XP_011518815.1,
XP_016874119.1,
XP_011518819.1,
NP_001374951.1,
XP_011518806.1,
XP_011518818.1,
XP_011518811.1,
XP_006718461.1,
XP_011518824.1,
XP_011518809.1
|
| Others |
UniRef100:
UniRef100_A0A2R8YEA1,
UniRef100_O15016
UniRef90:
UniRef90_O15016
UniRef50:
UniRef50_Q924W6
UniGene:
Hs.130836
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31753913 |
Genes Dev. Jae Jin Kim , Seo Yun Lee , Fade Gong , Anna M Battenhouse , Daniel R Boutz , Aarti Bashyal , Samantha T Refvik , Cheng-Ming Chiang , Blerta Xhemalce , Tanya T Paull , Jennifer S Brodbelt , Edward M Marcotte , Kyle M Miller |
2019-12-01 | - |
| 31472144 |
Life Sci. Tao He , Jie Cui , Yunhua Wu , Xuejun Sun , Nanzheng Chen |
2019-10-15 | - |
| 31537782 |
TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Nat Commun Jiajing Chen , Zikang Wang , Xudong Guo , Fudong Li , Qingtao Wei , Xuwen Chen , Deshun Gong , Yanxin Xu , Wen Chen , Yongrui Liu , Jiuhong Kang , Yunyu Shi |
2019-09-19 | - |
| 30710548 |
Eur. J. Pharmacol. Wanhu Fan , Fenjing Du , Xiaojing Liu |
2019-05-05 | - |
| 31434545 |
miR-451a Inhibits the Growth and Invasion of Osteosarcoma via Targeting TRIM66. Technol Cancer Res Treat Xiao Ma , Dan Li , Yan Gao , Cheng Liu |
2019-01-01 | - |
| 29929749 |
Pathol. Res. Pract. Huan-Yu Dai , Yan Ma , Zhao Da , Xiao-Ming Hou |
2018-08-01 | - |
| 28946563 |
TRIM66 expression in non-small cell lung cancer: A new predictor of prognosis. Cancer Biomark Yan Ma , Huan-Yu Dai , Feng Zhang , Da Zhao |
2017-09-07 | - |
| 26247633 |
Oncotarget Yu Chen , Yongfei Guo , Haisong Yang , Guodong Shi , Guohua Xu , Jiangang Shi , Na Yin , Deyu Chen |
2015-09-15 | - |
| 25231870 |
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature John Rb Perry , Felix Day , Cathy E Elks , Patrick Sulem , Deborah J Thompson , Teresa Ferreira , Chunyan He , Daniel I Chasman , Tõnu Esko , Gudmar Thorleifsson , Eva Albrecht , Wei Q Ang , Tanguy Corre , Diana L Cousminer , Bjarke Feenstra , Nora Franceschini , Andrea Ganna , Andrew D Johnson , Sanela Kjellqvist , Kathryn L Lunetta , George McMahon , Ilja M Nolte , Lavinia Paternoster , Eleonora Porcu , Albert V Smith , Lisette Stolk , Alexander Teumer , Natalia TÅ¡ernikova , Emmi Tikkanen , Sheila Ulivi , Erin K Wagner , Najaf Amin , Laura J Bierut , Enda M Byrne , Jouke-Jan Hottenga , Daniel L Koller , Massimo Mangino , Tune H Pers , Laura M Yerges-Armstrong , Jing Hua Zhao , Irene L Andrulis , Hoda Anton-Culver , Femke Atsma , Stefania Bandinelli , Matthias W Beckmann , Javier Benitez , Carl Blomqvist , Stig E Bojesen , Manjeet K Bolla , Bernardo Bonanni , Hiltrud Brauch , Hermann Brenner , Julie E Buring , Jenny Chang-Claude , Stephen Chanock , Jinhui Chen , Georgia Chenevix-Trench , J Margriet Collée , Fergus J Couch , David Couper , Andrea D Coveillo , Angela Cox , Kamila Czene , Adamo Pio D'adamo , George Davey Smith , Immaculata De Vivo , Ellen W Demerath , Joe Dennis , Peter Devilee , Aida K Dieffenbach , Alison M Dunning , Gudny Eiriksdottir , Johan G Eriksson , Peter A Fasching , Luigi Ferrucci , Dieter Flesch-Janys , Henrik Flyger , Tatiana Foroud , Lude Franke , Melissa E Garcia , Montserrat GarcÃa-Closas , Frank Geller , Eco Ej de Geus , Graham G Giles , Daniel F Gudbjartsson , Vilmundur Gudnason , Pascal Guénel , Suiqun Guo , Per Hall , Ute Hamann , Robin Haring , Catharina A Hartman , Andrew C Heath , Albert Hofman , Maartje J Hooning , John L Hopper , Frank B Hu , David J Hunter , David Karasik , Douglas P Kiel , Julia A Knight , Veli-Matti Kosma , Zoltan Kutalik , Sandra Lai , Diether Lambrechts , Annika Lindblom , Reedik Mägi , Patrik K Magnusson , Arto Mannermaa , Nicholas G Martin , Gisli Masson , Patrick F McArdle , Wendy L McArdle , Mads Melbye , Kyriaki Michailidou , Evelin Mihailov , Lili Milani , Roger L Milne , Heli Nevanlinna , Patrick Neven , Ellen A Nohr , Albertine J Oldehinkel , Ben A Oostra , Aarno Palotie , Munro Peacock , Nancy L Pedersen , Paolo Peterlongo , Julian Peto , Paul Dp Pharoah , Dirkje S Postma , Anneli Pouta , Katri Pylkäs , Paolo Radice , Susan Ring , Fernando Rivadeneira , Antonietta Robino , Lynda M Rose , Anja Rudolph , Veikko Salomaa , Serena Sanna , David Schlessinger , Marjanka K Schmidt , Mellissa C Southey , Ulla Sovio , Meir J Stampfer , Doris Stöckl , Anna M Storniolo , Nicholas J Timpson , Jonathan Tyrer , Jenny A Visser , Peter Vollenweider , Henry Völzke , Gerard Waeber , Melanie Waldenberger , Henri Wallaschofski , Qin Wang , Gonneke Willemsen , Robert Winqvist , Bruce Hr Wolffenbuttel , Margaret J Wright , Australian Ovarian Cancer Study , GENICA Network , kConFab , LifeLines Cohort Study , InterAct Consortium , Early Growth Genetics (EGG) Consortium , Dorret I Boomsma , Michael J Econs , Kay-Tee Khaw , Ruth Jf Loos , Mark I McCarthy , Grant W Montgomery , John P Rice , Elizabeth A Streeten , Unnur Thorsteinsdottir , Cornelia M van Duijn , Behrooz Z Alizadeh , Sven Bergmann , Eric Boerwinkle , Heather A Boyd , Laura Crisponi , Paolo Gasparini , Christian Gieger , Tamara B Harris , Erik Ingelsson , Marjo-Riitta Järvelin , Peter Kraft , Debbie Lawlor , Andres Metspalu , Craig E Pennell , Paul M Ridker , Harold Snieder , Thorkild Ia Sørensen , Tim D Spector , David P Strachan , André G Uitterlinden , Nicholas J Wareham , Elisabeth Widen , Marek Zygmunt , Anna Murray , Douglas F Easton , Kari Stefansson , Joanne M Murabito , Ken K Ong |
2014-10-02 | - |
| 23563607 |
Nat. Genet. Sonja I Berndt , Stefan Gustafsson , Reedik Mägi , Andrea Ganna , Eleanor Wheeler , Mary F Feitosa , Anne E Justice , Keri L Monda , Damien C Croteau-Chonka , Felix R Day , Tõnu Esko , Tove Fall , Teresa Ferreira , Davide Gentilini , Anne U Jackson , Jian'an Luan , Joshua C Randall , Sailaja Vedantam , Cristen J Willer , Thomas W Winkler , Andrew R Wood , Tsegaselassie Workalemahu , Yi-Juan Hu , Sang Hong Lee , Liming Liang , Dan-Yu Lin , Josine L Min , Benjamin M Neale , Gudmar Thorleifsson , Jian Yang , Eva Albrecht , Najaf Amin , Jennifer L Bragg-Gresham , Gemma Cadby , Martin den Heijer , Niina Eklund , Krista Fischer , Anuj Goel , Jouke-Jan Hottenga , Jennifer E Huffman , Ivonne Jarick , à sa Johansson , Toby Johnson , Stavroula Kanoni , Marcus E Kleber , Inke R König , Kati Kristiansson , Zoltán Kutalik , Claudia Lamina , Cecile Lecoeur , Guo Li , Massimo Mangino , Wendy L McArdle , Carolina Medina-Gomez , Martina Müller-Nurasyid , Julius S Ngwa , Ilja M Nolte , Lavinia Paternoster , Sonali Pechlivanis , Markus Perola , Marjolein J Peters , Michael Preuss , Lynda M Rose , Jianxin Shi , Dmitry Shungin , Albert Vernon Smith , Rona J Strawbridge , Ida Surakka , Alexander Teumer , Mieke D Trip , Jonathan Tyrer , Jana V Van Vliet-Ostaptchouk , Liesbeth Vandenput , Lindsay L Waite , Jing Hua Zhao , Devin Absher , Folkert W Asselbergs , Mustafa Atalay , Antony P Attwood , Anthony J Balmforth , Hanneke Basart , John Beilby , Lori L Bonnycastle , Paolo Brambilla , Marcel Bruinenberg , Harry Campbell , Daniel I Chasman , Peter S Chines , Francis S Collins , John M Connell , William O Cookson , Ulf de Faire , Femmie de Vegt , Mariano Dei , Maria Dimitriou , Sarah Edkins , Karol Estrada , David M Evans , Martin Farrall , Marco M Ferrario , Jean Ferrières , Lude Franke , Francesca Frau , Pablo V Gejman , Harald Grallert , Henrik Grönberg , Vilmundur Gudnason , Alistair S Hall , Per Hall , Anna-Liisa Hartikainen , Caroline Hayward , Nancy L Heard-Costa , Andrew C Heath , Johannes Hebebrand , Georg Homuth , Frank B Hu , Sarah E Hunt , Elina Hyppönen , Carlos Iribarren , Kevin B Jacobs , John-Olov Jansson , Antti Jula , Mika Kähönen , Sekar Kathiresan , Frank Kee , Kay-Tee Khaw , Mika Kivimäki , Wolfgang Koenig , Aldi T Kraja , Meena Kumari , Kari Kuulasmaa , Johanna Kuusisto , Jaana H Laitinen , Timo A Lakka , Claudia Langenberg , Lenore J Launer , Lars Lind , Jaana Lindström , Jianjun Liu , Antonio Liuzzi , Marja-Liisa Lokki , Mattias Lorentzon , Pamela A Madden , Patrik K Magnusson , Paolo Manunta , Diana Marek , Winfried März , Irene Mateo Leach , Barbara McKnight , Sarah E Medland , Evelin Mihailov , Lili Milani , Grant W Montgomery , Vincent Mooser , Thomas W Mühleisen , Patricia B Munroe , Arthur W Musk , Narisu Narisu , Gerjan Navis , George Nicholson , Ellen A Nohr , Ken K Ong , Ben A Oostra , Colin N A Palmer , Aarno Palotie , John F Peden , Nancy Pedersen , Annette Peters , Ozren Polasek , Anneli Pouta , Peter P Pramstaller , Inga Prokopenko , Carolin Pütter , Aparna Radhakrishnan , Olli Raitakari , Augusto Rendon , Fernando Rivadeneira , Igor Rudan , Timo E Saaristo , Jennifer G Sambrook , Alan R Sanders , Serena Sanna , Jouko Saramies , Sabine Schipf , Stefan Schreiber , Heribert Schunkert , So-Youn Shin , Stefano Signorini , Juha Sinisalo , Boris Skrobek , Nicole Soranzo , Alena StanÄáková , Klaus Stark , Jonathan C Stephens , Kathleen Stirrups , Ronald P Stolk , Michael Stumvoll , Amy J Swift , Eirini V Theodoraki , Barbara Thorand , David-Alexandre Tregouet , Elena Tremoli , Melanie M Van der Klauw , Joyce B J van Meurs , Sita H Vermeulen , Jorma Viikari , Jarmo Virtamo , Veronique Vitart , Gérard Waeber , Zhaoming Wang , Elisabeth Widén , Sarah H Wild , Gonneke Willemsen , Bernhard R Winkelmann , Jacqueline C M Witteman , Bruce H R Wolffenbuttel , Andrew Wong , Alan F Wright , M Carola Zillikens , Philippe Amouyel , Bernhard O Boehm , Eric Boerwinkle , Dorret I Boomsma , Mark J Caulfield , Stephen J Chanock , L Adrienne Cupples , Daniele Cusi , George V Dedoussis , Jeanette Erdmann , Johan G Eriksson , Paul W Franks , Philippe Froguel , Christian Gieger , Ulf Gyllensten , Anders Hamsten , Tamara B Harris , Christian Hengstenberg , Andrew A Hicks , Aroon Hingorani , Anke Hinney , Albert Hofman , Kees G Hovingh , Kristian Hveem , Thomas Illig , Marjo-Riitta Jarvelin , Karl-Heinz Jöckel , Sirkka M Keinanen-Kiukaanniemi , Lambertus A Kiemeney , Diana Kuh , Markku Laakso , Terho Lehtimäki , Douglas F Levinson , Nicholas G Martin , Andres Metspalu , Andrew D Morris , Markku S Nieminen , Inger Njølstad , Claes Ohlsson , Albertine J Oldehinkel , Willem H Ouwehand , Lyle J Palmer , Brenda Penninx , Chris Power , Michael A Province , Bruce M Psaty , Lu Qi , Rainer Rauramaa , Paul M Ridker , Samuli Ripatti , Veikko Salomaa , Nilesh J Samani , Harold Snieder , Thorkild I A Sørensen , Timothy D Spector , Kari Stefansson , Anke Tönjes , Jaakko Tuomilehto , André G Uitterlinden , Matti Uusitupa , Pim van der Harst , Peter Vollenweider , Henri Wallaschofski , Nicholas J Wareham , Hugh Watkins , H-Erich Wichmann , James F Wilson , Goncalo R Abecasis , Themistocles L Assimes , Inês Barroso , Michael Boehnke , Ingrid B Borecki , Panos Deloukas , Caroline S Fox , Timothy Frayling , Leif C Groop , Talin Haritunian , Iris M Heid , David Hunter , Robert C Kaplan , Fredrik Karpe , Miriam F Moffatt , Karen L Mohlke , Jeffrey R O'Connell , Yudi Pawitan , Eric E Schadt , David Schlessinger , Valgerdur Steinthorsdottir , David P Strachan , Unnur Thorsteinsdottir , Cornelia M van Duijn , Peter M Visscher , Anna Maria Di Blasio , Joel N Hirschhorn , Cecilia M Lindgren , Andrew P Morris , David Meyre , André Scherag , Mark I McCarthy , Elizabeth K Speliotes , Kari E North , Ruth J F Loos , Erik Ingelsson |
2013-05-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员