| Type | Description |
|---|---|
| Definition | GRB2 associated binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:26:00 | The miR-218/GAB2 axis regulates proliferation, invasion and EMT via the PI3K/AKT/GSK-3beta pathway in prostate cancer. | 32522441 |
| 2020-10-31 13:14:00 | Mapping the allosteric network within a SH3 domain. | 31164678 |
| 2020-10-31 13:13:00 | MiR-125a-5p inhibits the proliferation and invasion of breast cancer cells and induces apoptosis by targeting GAB2. | 31698596 |
| 2020-06-27 10:51:00 | Gab2 overexpression increased the number of ALDH(+) cells and tumorsphere formation in two different ovarian cancer cell lines OVCAR5 and OVCAR8, whereas knockdown of Gab2 decreased the number of ALDH(+) cells and tumorsphere formation in Caov-3cells. Gab2 via PI3K specifically inhibited miR-200c expression. Gab2 promoted CD44 expression and cell migration/invasion through miR-200c downregulation. | 31194976 |
| 2019-08-03 10:07:00 | The restoration of miR-663b expression inhibited cell proliferation and invasion in HCC through directly targeting and inhibiting GAB2. | 30720118 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GAB2_HUMAN
UniprotKB:
Q9UQC2
UniParc:
UPI0000073037,
UPI00001615CF
EMBL:
AP002985,
BC152459,
AB011143,
BC131711,
AB018413,
CH471076
Ensembl:
ENSG00000033327
KO:
hsa:9846
|
| Nucleutide sequences |
EMBL-CDS:
AAI31712.1,
EAW75058.1,
AAI52460.1,
BAA76737.1,
BAA25497.2,
EAW75057.1
Ensembl_TRS:
ENST00000340149,
ENST00000361507
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000343959,
ENSP00000354952
RefSeq:
XP_011543710.1,
NP_036428.1,
XP_024304550.1,
XP_006718816.1,
NP_536739.1
|
| Others |
UniRef100:
UniRef100_Q9UQC2
UniRef90:
UniRef90_Q9UQC2
UniRef50:
UniRef50_Q9UQC2
UniGene:
Hs.429434
CCDS:
CCDS8260.1,
CCDS8259.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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