| Type | Description |
|---|---|
| Definition | PH domain and leucine rich repeat protein phosphatase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 15:29:00 | Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. | 31582730 |
| 2020-07-11 12:46:00 | CXCL13 is an adipocytokine that facilitates hypoxia-induced inflammation in adipocytes through FAK-mediated induction of PHLPP1 in autocrine and/or paracrine manner. | 31710352 |
| 2020-03-21 11:02:00 | Phlpp1 deficiency increases activity of a isoform controlling cell polarity, and that addition of a pseudosubstrate restores osteoclastogenesis and bone resorption of Phlpp1-deficient osteoclasts. Moreover, Phlpp1 deficiency increased expression of the bone-coupling factor collagen triple helix repeat-containing 1 (Cthrc1) | 31189651 |
| 2020-02-01 10:57:00 | Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor on Ser727 to inhibit its activity, reduce its promoter residency, and reduce the expression of target genes involved in innate immunity and cytokine signaling. | 31408005 |
| 2019-10-19 11:40:00 | FoxO3a transcription factor regulates PHLPP1 expression in chondrocytes. The crucial role of DNA methylation in controlling PHLPP1 transcription is also supported. | 29775231 |
| Type | IDs |
|---|---|
| Synonymous | AI836256, Phlpp, Plekhe1, SCOP, mKIAA0606 |
| Gene |
UniProtKB-ID:
PHLP1_MOUSE
UniprotKB:
Q8CHE4
UniParc:
UPI000024ED87,
UPI0001AFF975
EMBL:
BC059254,
BC024670,
AC101663,
AC144773,
AB093251,
AC124710,
BC004581,
BC022703
Ensembl:
ENSMUSG00000044340
KO:
mmu:98432
|
| Nucleutide sequences |
EMBL-CDS:
AAH04581.1,
AAH22703.1,
AAH24670.1,
BAC41435.1,
AAH59254.1
Ensembl_TRS:
ENSMUST00000061047
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000056530
RefSeq:
NP_598582.3
|
| Others |
UniRef100:
UniRef100_Q8CHE4
UniRef90:
UniRef90_Q8CHE4
UniRef50:
UniRef50_Q9WTR8
UniGene:
Mm.24115
CCDS:
CCDS48337.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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