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9843 HEPH

9843

HEPH

hephaestin

protein-coding

Homo sapiens

基因描述

Type Description
Definition hephaestin

研究结论

Date Results Publications
2020-09-26 13:03:00 Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption. 31973819
2019-06-01 11:10:00 Iron supplementation increased surface expression of the iron-efflux complex, and copper depletion knocked down hephaestin (Heph) activity and decreased ferroportin (Fpn) membrane localization. 30647129
2015-03-28 13:15:00 This review describes function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein. 24988611
2013-08-31 12:04:00 Iron efflux from human brain microvasculature endothelial cells ferroportin requires the action of an exocytoplasmic ferroxidase which can be either endogenous hephaestin or extracellular ceruloplasmin. 23640881
2012-08-04 11:43:00 Heph is active in placenta but may not play a key role in placental iron transport. 22170436

名称对应

Type IDs
Synonymous CPL
Gene
UniProtKB-ID: HEPH_HUMAN, A0A0C4DG76_HUMAN, E7ES21_HUMAN
UniprotKB: Q9BQS7, A0A0C4DG76, E7ES21
UniParc: UPI0001891CBC, UPI000004D26F, UPI000004D26E, UPI000004C643, UPI0001C06560, UPI0000443FB4
EMBL: AF148860, CH471132, KF459144, AL157698, AB014598, AY358990, AJ296162, KF459146, AL030998, BC011561
Ensembl: ENSG00000089472
KO: hsa:9843
Nucleutide sequences
EMBL-CDS: BAA31673.2, EAX05384.1, EAX05385.1, AAH11561.1, EAX05388.1, AAQ89349.1, AAK08131.1, EAX05386.1, CAC35365.2, EAX05387.1
Gene_ORFName: UNQ2562/PRO6242, hCG_18329
Ensembl_TRS: ENST00000336279, ENST00000343002, ENST00000519389, ENST00000441993, ENST00000419594
Protein sequencees
Ensembl_PRO: ENSP00000337418, ENSP00000430620, ENSP00000343939, ENSP00000411687, ENSP00000413211
RefSeq: NP_055614.1, NP_001354168.1, NP_001354165.1, XP_011529376.1, XP_011529377.1, NP_001269070.1, NP_001354171.1, NP_001354167.1, NP_001354161.1, NP_001354170.1, NP_001354162.1, NP_001354163.1, NP_001354169.1, NP_001124332.1, NP_001354172.1, XP_011529375.1, XP_016885487.1, NP_620074.3
Others
UniRef100: UniRef100_E7ES21, UniRef100_Q9BQS7, UniRef100_A0A0C4DG76
UniRef90: UniRef90_F7H208, UniRef90_Q9BQS7, UniRef90_A0A5K1TVT7
UniRef50: UniRef50_Q9Z0Z4, UniRef50_Q9BQS7
UniGene: Hs.31720
CCDS: CCDS14384.3, CCDS14385.1

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