| Type | Description |
|---|---|
| Definition | pleckstrin homology and RUN domain containing M1 |
| Date | Results | Publications |
|---|---|---|
| 2016-03-19 11:18:00 | identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome | 25905573 |
| 2015-10-10 10:58:00 | Authors show that Pleckstrin homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA. | 25500191 |
| 2015-04-11 10:40:00 | PLEKHM1 regulates autophagosome-lysosome fusion through homotypic fusion and protein sorting complex and LC3/GABARAP proteins. | 25498145 |
| 2011-06-25 15:01:00 | Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase | 20943950 |
| 2010-01-21 00:00:00 | PLEKHM1 is a novel gene implicated in the development of osteopetrosis, with a putative critical function in vesicular transport in the osteoclast. | 17404618 |
| Type | IDs |
|---|---|
| Synonymous | AP162, B2, OPTA3, OPTB6 |
| Gene |
UniProtKB-ID:
PKHM1_HUMAN
UniprotKB:
Q9Y4G2
UniParc:
UPI00001C1FC4
EMBL:
AK074103,
AB002354,
BC064361,
AJ002220,
AL389948
Ensembl:
ENSG00000276358,
ENSG00000277111,
ENSG00000225190
KO:
hsa:9842
|
| Nucleutide sequences |
EMBL-CDS:
CAB91652.1,
BAA20813.2,
BAB84929.1,
AAH64361.1,
CAB97526.1
Ensembl_TRS:
ENST00000613787,
ENST00000617688,
ENST00000430334
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000389913,
ENSP00000483820,
ENSP00000479066
RefSeq:
XP_016880943.1,
XP_011523827.1,
XP_016880941.1,
NP_001339754.1,
XP_011523826.1,
XP_016880942.1,
XP_011523825.1,
XP_006722264.1,
XP_011523830.1,
NP_055613.1,
XP_011523828.1,
XP_016880940.1
|
| Others |
UniRef100:
UniRef100_Q9Y4G2
UniRef90:
UniRef90_Q9Y4G2
UniRef50:
UniRef50_Q9Y4G2
UniGene:
Hs.514242
CCDS:
CCDS32671.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31391242 |
DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. J Cell Sci Marcel Nowak , Benjamin Suenkel , Pablo Porras , Rebekka Migotti , Franziska Schmidt , Melanie Kny , Xiaoxi Zhu , Erich E Wanker , Gunnar Dittmar , Jens Fielitz , Thomas Sommer |
2019-09-06 | - |
| 30232004 |
Cell Rep Christopher G Abraham , Michael P Ludwig , Zdenek Andrysik , Ahwan Pandey , Molishree Joshi , Matthew D Galbraith , Kelly D Sullivan , Joaquin M Espinosa |
2018-09-18 | - |
| 29507755 |
Cell Discov Yanan Yue , Jun Liu , Xiaolong Cui , Jie Cao , Guanzheng Luo , Zezhou Zhang , Tao Cheng , Minsong Gao , Xiao Shu , Honghui Ma , Fengqin Wang , Xinxia Wang , Bin Shen , Yizhen Wang , Xinhua Feng , Chuan He , Jianzhao Liu |
2018-01-01 | - |
| 28611215 |
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown |
2017-06-27 | - |
| 27777970 |
PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight Toshifumi Fujiwara , Shiqiao Ye , Thiago Castro-Gomes , Caylin G Winchell , Norma W Andrews , Daniel E Voth , Kottayil I Varughese , Samuel G Mackintosh , Yunfeng Feng , Nathan Pavlos , Takashi Nakamura , Stavros C Manolagas , Haibo Zhao |
2016-10-20 | - |
| 25905573 |
PLEKHM1: Adapting to life at the lysosome. Autophagy David G McEwan , Ivan Dikic |
2015-04-03 | - |
| 25500191 |
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe David G McEwan , Benjamin Richter , Beatrice Claudi , Christoph Wigge , Philipp Wild , Hesso Farhan , Kieran McGourty , Fraser P Coxon , Mirita Franz-Wachtel , Bram Perdu , Masato Akutsu , Anja Habermann , Anja Kirchof , Miep H Helfrich , Paul R Odgren , Wim Van Hul , Achilleas S Frangakis , Krishnaraj Rajalingam , Boris Macek , David W Holden , Dirk Bumann , Ivan Dikic |
2015-01-14 | - |
| 25498145 |
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol Cell David G McEwan , Doris Popovic , Andrea Gubas , Seigo Terawaki , Hironori Suzuki , Daniela Stadel , Fraser P Coxon , Diana Miranda de Stegmann , Sagar Bhogaraju , Karthik Maddi , Anja Kirchof , Evelina Gatti , Miep H Helfrich , Soichi Wakatsuki , Christian Behrends , Philippe Pierre , Ivan Dikic |
2015-01-08 | - |
| 23544013 |
PLoS Genet Fergus J Couch , Xianshu Wang , Lesley McGuffog , Andrew Lee , Curtis Olswold , Karoline B Kuchenbaecker , Penny Soucy , Zachary Fredericksen , Daniel Barrowdale , Joe Dennis , Mia M Gaudet , Ed Dicks , Matthew Kosel , Sue Healey , Olga M Sinilnikova , Adam Lee , François Bacot , Daniel Vincent , Frans B L Hogervorst , Susan Peock , Dominique Stoppa-Lyonnet , Anna Jakubowska , kConFab Investigators , Paolo Radice , Rita Katharina Schmutzler , SWE-BRCA , Susan M Domchek , Marion Piedmonte , Christian F Singer , Eitan Friedman , Mads Thomassen , Ontario Cancer Genetics Network , Thomas V O Hansen , Susan L Neuhausen , Csilla I Szabo , Ignacio Blanco , Mark H Greene , Beth Y Karlan , Judy Garber , Catherine M Phelan , Jeffrey N Weitzel , Marco Montagna , Edith Olah , Irene L Andrulis , Andrew K Godwin , Drakoulis Yannoukakos , David E Goldgar , Trinidad Caldes , Heli Nevanlinna , Ana Osorio , Mary Beth Terry , Mary B Daly , Elizabeth J van Rensburg , Ute Hamann , Susan J Ramus , Amanda Ewart Toland , Maria A Caligo , Olufunmilayo I Olopade , Nadine Tung , Kathleen Claes , Mary S Beattie , Melissa C Southey , Evgeny N Imyanitov , Marc Tischkowitz , Ramunas Janavicius , Esther M John , Ava Kwong , Orland Diez , Judith Balmaña , Rosa B Barkardottir , Banu K Arun , Gad Rennert , Soo-Hwang Teo , Patricia A Ganz , Ian Campbell , Annemarie H van der Hout , Carolien H M van Deurzen , Caroline Seynaeve , Encarna B Gómez Garcia , Flora E van Leeuwen , Hanne E J Meijers-Heijboer , Johannes J P Gille , Margreet G E M Ausems , Marinus J Blok , Marjolijn J L Ligtenberg , Matti A Rookus , Peter Devilee , Senno Verhoef , Theo A M van Os , Juul T Wijnen , HEBON , EMBRACE , Debra Frost , Steve Ellis , Elena Fineberg , Radka Platte , D Gareth Evans , Louise Izatt , Rosalind A Eeles , Julian Adlard , Diana M Eccles , Jackie Cook , Carole Brewer , Fiona Douglas , Shirley Hodgson , Patrick J Morrison , Lucy E Side , Alan Donaldson , Catherine Houghton , Mark T Rogers , Huw Dorkins , Jacqueline Eason , Helen Gregory , Emma McCann , Alex Murray , Alain Calender , Agnès Hardouin , Pascaline Berthet , Capucine Delnatte , Catherine Nogues , Christine Lasset , Claude Houdayer , Dominique Leroux , Etienne Rouleau , Fabienne Prieur , Francesca Damiola , Hagay Sobol , Isabelle Coupier , Laurence Venat-Bouvet , Laurent Castera , Marion Gauthier-Villars , Mélanie Léoné , Pascal Pujol , Sylvie Mazoyer , Yves-Jean Bignon , GEMO Study Collaborators , Elżbieta ZÅowocka-PerÅowska , Jacek Gronwald , Jan Lubinski , Katarzyna Durda , Katarzyna Jaworska , Tomasz Huzarski , Amanda B Spurdle , Alessandra Viel , Bernard Peissel , Bernardo Bonanni , Giulia Melloni , Laura Ottini , Laura Papi , Liliana Varesco , Maria Grazia Tibiletti , Paolo Peterlongo , Sara Volorio , Siranoush Manoukian , Valeria Pensotti , Norbert Arnold , Christoph Engel , Helmut Deissler , Dorothea Gadzicki , Andrea Gehrig , Karin Kast , Kerstin Rhiem , Alfons Meindl , Dieter Niederacher , Nina Ditsch , Hansjoerg Plendl , Sabine Preisler-Adams , Stefanie Engert , Christian Sutter , Raymonda Varon-Mateeva , Barbara Wappenschmidt , Bernhard H F Weber , Brita Arver , Marie Stenmark-Askmalm , Niklas Loman , Richard Rosenquist , Zakaria Einbeigi , Katherine L Nathanson , Timothy R Rebbeck , Stephanie V Blank , David E Cohn , Gustavo C Rodriguez , Laurie Small , Michael Friedlander , Victoria L Bae-Jump , Anneliese Fink-Retter , Christine Rappaport , Daphne Gschwantler-Kaulich , Georg Pfeiler , Muy-Kheng Tea , Noralane M Lindor , Bella Kaufman , Shani Shimon Paluch , Yael Laitman , Anne-Bine Skytte , Anne-Marie Gerdes , Inge Sokilde Pedersen , Sanne Traasdahl Moeller , Torben A Kruse , Uffe Birk Jensen , Joseph Vijai , Kara Sarrel , Mark Robson , Noah Kauff , Anna Marie Mulligan , Gord Glendon , Hilmi Ozcelik , Bent Ejlertsen , Finn C Nielsen , Lars Jønson , Mette K Andersen , Yuan Chun Ding , Linda Steele , Lenka Foretova , Alex Teulé , Conxi Lazaro , Joan Brunet , Miquel Angel Pujana , Phuong L Mai , Jennifer T Loud , Christine Walsh , Jenny Lester , Sandra Orsulic , Steven A Narod , Josef Herzog , Sharon R Sand , Silvia Tognazzo , Simona Agata , Tibor Vaszko , Joellen Weaver , Alexandra V Stavropoulou , Saundra S Buys , Atocha Romero , Miguel de la Hoya , Kristiina Aittomäki , Taru A Muranen , Mercedes Duran , Wendy K Chung , Adriana Lasa , Cecilia M Dorfling , Alexander Miron , BCFR , Javier Benitez , Leigha Senter , Dezheng Huo , Salina B Chan , Anna P Sokolenko , Jocelyne Chiquette , Laima Tihomirova , Tara M Friebel , Bjarni A Agnarsson , Karen H Lu , Flavio Lejbkowicz , Paul A James , Per Hall , Alison M Dunning , Daniel Tessier , Julie Cunningham , Susan L Slager , Chen Wang , Steven Hart , Kristen Stevens , Jacques Simard , Tomi Pastinen , Vernon S Pankratz , Kenneth Offit , Douglas F Easton , Georgia Chenevix-Trench , Antonis C Antoniou , CIMBA |
2013-01-01 | - |
| 21900206 |
A directed protein interaction network for investigating intracellular signal transduction. Sci Signal Arunachalam Vinayagam , Ulrich Stelzl , Raphaele Foulle , Stephanie Plassmann , Martina Zenkner , Jan Timm , Heike E Assmus , Miguel A Andrade-Navarro , Erich E Wanker |
2011-09-06 |
KCNE3,
HDAC6,
PDCD6IP,
ZNF605,
TOM1L1,
HMGXB4,
RANBP9,
RWDD2B,
SNUPN,
TSSC4,
ARPC3,
ACTR1B,
CDH13,
CEBPZ,
RBM5,
CDK4,
CDK5,
TRIM13,
EIF1,
DDX39A,
HNRNPR,
RABEPK,
SPRY2,
CDKN1A,
CDK2AP2,
LOC400927-CSNK1E,
RGS19,
CDKN2B,
DSCR3,
IKZF1,
NPM3,
TUBA1B,
TUBB3,
RACK1,
PIAS3,
NDC80,
YAP1,
CDIPT,
TUBGCP3,
TIMM17A,
TAB1,
FST,
STK25,
DEAF1,
KAT5,
GLRX3,
DCTN2,
PRDX4,
RABAC1,
DPYSL4,
CCT7,
CCT4,
DRAP1,
CENPB,
TXNIP,
NPRL2,
GNB5,
CERS1,
CFL1,
MGEA5,
PLK4,
RAI1,
GIPC1,
ZNF266,
UTP14A,
PGRMC1,
RAB10,
YIF1A,
JTB,
GADD45G,
AFG3L2,
C11orf58,
HNRNPA0,
PNRC1,
ADIRF,
COPS6,
IMMT,
SF3B2,
KIF2C,
RAB31,
ADAP1,
PIM2,
RCC1,
NUDT21,
SNRNP35,
CHD3,
STMN2,
HSF2BP,
SPACA9,
RPP14,
FGFR1OP,
FAF1,
ZWINT,
CHGA,
CDC37,
CHGB,
KAT7,
C14orf1,
NUDT5
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员