| Type | Description |
|---|---|
| Definition | leucine carboxyl methyltransferase 2 |
| Date | Results | Publications |
|---|---|---|
| 2012-04-28 11:45:00 | Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A. | 22253232 |
| 2010-12-06 16:13:00 | This paper reports crystal structures of a yeast homolog, TYW4. | 19287006 |
| 2010-01-21 00:00:00 | p21WAF1 and Bax may be used as the markers in the assessment of GIST malignant potential. | 16830365 |
| 2010-01-21 00:00:00 | In conclusion, we report that the transcription factor Sp1 involved in the p38MAPK-mediated control of p21WAF1 regulation on VSMC in response to BITC has now been identified. | 17026958 |
| 2010-01-21 00:00:00 | Inacativaton of this cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders. | 15813917 |
| Type | IDs |
|---|---|
| Synonymous | PPM2, TYW4 |
| Gene |
UniProtKB-ID:
TYW4_HUMAN
UniprotKB:
O60294
UniParc:
UPI00000727F6
EMBL:
AB011119,
DQ102852,
AF265443,
BC015949
Ensembl:
ENSG00000168806
KO:
hsa:9836
|
| Nucleutide sequences |
EMBL-CDS:
AAF75774.1,
AAY88744.1,
AAH15949.1,
BAA25473.2
Ensembl_TRS:
ENST00000305641
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000307214
RefSeq:
NP_055608.2
|
| Others |
UniRef100:
UniRef100_O60294
UniRef90:
UniRef90_O60294
UniRef50:
UniRef50_O60294
UniGene:
Hs.200596,
Hs.533913,
Hs.745356
CCDS:
CCDS10094.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 30585266 |
Wentao Zhang , Ning Duan , Qian Zhang , Tao Song , Zhong Li , Xun Chen , Kunzheng Wang |
2018-01-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 26344197 |
Panorama of ancient metazoan macromolecular complexes. Nature Cuihong Wan , Blake Borgeson , Sadhna Phanse , Fan Tu , Kevin Drew , Greg Clark , Xuejian Xiong , Olga Kagan , Julian Kwan , Alexandr Bezginov , Kyle Chessman , Swati Pal , Graham Cromar , Ophelia Papoulas , Zuyao Ni , Daniel R Boutz , Snejana Stoilova , Pierre C Havugimana , Xinghua Guo , Ramy H Malty , Mihail Sarov , Jack Greenblatt , Mohan Babu , W Brent Derry , Elisabeth R Tillier , John B Wallingford , John Parkinson , Edward M Marcotte , Andrew Emili |
2015-09-17 |
AKT3,
MED6,
ABI1,
GNPDA1,
SRA1,
TDRD15,
HMGN1P30,
PDCD6IP,
PDCD6,
MED16,
ADA,
CHAF1A,
TOM1,
RANBP9,
SMC4,
ARPC4-TTLL3,
RBM14-RBM4,
RNF103-CHMP3,
CHURC1-FNTB,
AP1M2,
ISY1-RAB43,
UBA2,
SAE1,
FARSB,
DNM1L,
ABCF2,
COX17,
SCAMP2,
SCAMP3,
DPP3,
SNUPN,
HUWE1,
TSSC4,
ATP9A,
PQBP1,
COL4A3BP,
PTGES3L-AARSD1,
ARPC5,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
NUBP2,
PPIF,
LOC101060521,
ARPC2,
RAD50,
ACTR1B,
ACTR1A,
ADAM8,
LRPPRC,
PDIA6,
TRAP1,
BCAP31,
NAMPT,
RBM12,
G3BP1,
ABI2,
CEBPZ,
TRIM28,
AASS,
ATP6AP2,
WASF2,
SLC25A13,
CDK2,
RBM7,
ALYREF,
TXNDC9,
LOC101929876,
PSME3,
MPHOSPH10,
MPHOSPH6,
CDK5,
NUTF2,
EIF1,
DDX39A,
PSMD14,
CDK7,
PLIN3,
HNRNPR,
MRPS31,
CDK8,
RABEPK,
RIDA,
SRRM1,
CDK9,
STAM2,
SF3B4,
ZMPSTE24,
AKAP8,
STUB1,
STAG1,
UBE4B,
PRSS16,
SIGMAR1,
BET1,
CWC27,
SAP18
|
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 25921289 |
Sci Signal Kristina B Emdal , Anna-Kathrine Pedersen , Dorte B Bekker-Jensen , Kalliopi P Tsafou , Heiko Horn , Sven Lindner , Johannes H Schulte , Angelika Eggert , Lars J Jensen , Chiara Francavilla , Jesper V Olsen |
2015-04-28 | - |
| 25910212 |
Widespread macromolecular interaction perturbations in human genetic disorders. Cell Nidhi Sahni , Song Yi , Mikko Taipale , Juan I Fuxman Bass , Jasmin Coulombe-Huntington , Fan Yang , Jian Peng , Jochen Weile , Georgios I Karras , Yang Wang , István A Kovács , Atanas Kamburov , Irina Krykbaeva , Mandy H Lam , George Tucker , Vikram Khurana , Amitabh Sharma , Yang-Yu Liu , Nozomu Yachie , Quan Zhong , Yun Shen , Alexandre Palagi , Adriana San-Miguel , Changyu Fan , Dawit Balcha , Amelie Dricot , Daniel M Jordan , Jennifer M Walsh , Akash A Shah , Xinping Yang , Ani K Stoyanova , Alex Leighton , Michael A Calderwood , Yves Jacob , Michael E Cusick , Kourosh Salehi-Ashtiani , Luke J Whitesell , Shamil Sunyaev , Bonnie Berger , Albert-László Barabási , Benoit Charloteaux , David E Hill , Tong Hao , Frederick P Roth , Yu Xia , Albertha J M Walhout , Susan Lindquist , Marc Vidal |
2015-04-23 | - |
| 22253232 |
KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. Cancer Res. Bu-Nam Jeon , Min-Kyeong Kim , Won-Il Choi , Dong-In Koh , Sung-Yi Hong , Kyung-Sup Kim , Minjung Kim , Chae-Ok Yun , Juyong Yoon , Kang-Yell Choi , Kyung-Ryul Lee , Kenneth P Nephew , Man-Wook Hur |
2012-03-01 |
Hdac3,
Ncor1,
Zbtb7c,
Trp53,
Bcor,
ZBTB7C,
LCMT2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 19287006 |
Nucleic Acids Res. Yoko Suzuki , Akiko Noma , Tsutomu Suzuki , Ryuichiro Ishitani , Osamu Nureki |
2009-05-01 |
PPM2,
LCMT2
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员