| Type | Description |
|---|---|
| Definition | TSC22 domain family member 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:33:00 | Genome-wide linkage analysis and whole-exome sequencing in a rare, large multi-cancer pedigree recently found in China identified a novel mutant of transforming growth factor beta stimulated clone 22 domain family, member 2 (TSC22D2, c.-91T-C) cosegregated with the cancer phenotype. Study found that histone H4 transcription factor (HINFP) binds to the promoter region of TSC22D2 and may regulate its transcription. | 31125406 |
| 2017-04-08 10:54:00 | Results found TSC22D2 significantly downregulated in colorectal cancer (CRC). Its overexpression can inhibit CRC cell growth. Also, TSC22D2 physically associates with PKM2, and demonstrated that TSC22D2 overexpression reduces nuclear PKM2 levels and represses the expression of cyclin D1. | 27573352 |
| 2017-02-18 11:38:00 | TSC22D2 protein might be a member of the PRMT5 complex via direct binding of WDR77. | 27337956 |
| 2010-10-29 17:10:00 | Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. | 20149264 |
| Type | IDs |
|---|---|
| Synonymous | TILZ4a, TILZ4b, TILZ4c |
| Gene |
UniProtKB-ID:
T22D2_HUMAN,
B4DN36_HUMAN
UniprotKB:
O75157,
B4DN36
UniParc:
UPI000036FB1D,
UPI000020A44C,
UPI00000722E0
EMBL:
AF201290,
BC044643,
CH471052,
AF201292,
AF201291,
AK297748,
AB014569
Ensembl:
ENSG00000196428
KO:
hsa:9819
|
| Nucleutide sequences |
EMBL-CDS:
BAA31644.2,
EAW78839.1,
AAG41225.1,
AAG41224.1,
AAG41223.1,
EAW78838.1,
AAH44643.1,
EAW78841.1,
BAG60098.1
Gene_ORFName:
hCG_21344
Ensembl_TRS:
ENST00000361875
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354543
RefSeq:
XP_011511639.1,
NP_001290193.1,
NP_055594.1
|
| Others |
UniRef100:
UniRef100_B4DN36,
UniRef100_O75157
UniRef90:
UniRef90_O75157,
UniRef90_G3SEW9
UniRef50:
UniRef50_O75157
UniGene:
Hs.722470,
Hs.730710
CCDS:
CCDS3149.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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