| Type | Description |
|---|---|
| Definition | FERM and PDZ domain containing 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:22:00 | Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. | 33216857 |
| 2019-01-12 11:25:00 | The findings point to an important role of FRMPD4 in normal cognitive development and function in humans and mice, and support the hypothesis that FRMPD4 mutations cause ID by disrupting dendritic spine morphogenesis in glutamatergic neurons. | 29267967 |
| 2016-09-03 11:41:00 | Study suggests that the variant rs5979717 in FRMPD4 may play a role in schizophrenia etiology in females | 26555035 |
| 2015-11-07 11:36:00 | A crystal structure of Frmpd4-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4. | 25664792 |
| 2010-10-22 12:44:00 | Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the betaPix-based Rac1 signaling pathway. | 19118189 |
| Type | IDs |
|---|---|
| Synonymous | MRX104, PDZD10, PDZK10 |
| Gene |
UniProtKB-ID:
FRPD4_HUMAN
UniprotKB:
Q14CM0
UniParc:
UPI00001C2066
EMBL:
AB002314,
BC113700,
BC113702,
AK289694
Ensembl:
ENSG00000169933
KO:
hsa:9758
|
| Nucleutide sequences |
EMBL-CDS:
AAI13701.1,
AAI13703.1,
BAF82383.1,
BAA20774.3
Ensembl_TRS:
ENST00000380682
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370057
RefSeq:
NP_001355325.1,
XP_016885472.1,
NP_001355324.1,
XP_016885474.1,
NP_001355331.1,
NP_001355327.1,
NP_001355329.1,
NP_001355328.1,
NP_055543.2,
XP_005274689.2,
XP_016885473.1,
NP_001355326.1,
NP_001355330.1
|
| Others |
UniRef100:
UniRef100_Q14CM0
UniRef90:
UniRef90_Q14CM0
UniRef50:
UniRef50_Q14CM0
UniGene:
Hs.657507
CCDS:
CCDS35201.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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