| Type | Description |
|---|---|
| Definition | TRPM8 channel associated factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2016-01-27 16:36:00 | TCAF1 binds to and promotes trafficking of the TRPM8 cold sensor channel to the cell surface, it contains a PI3K homology domain in its C-terminal tail that modifies TRPM8 gating properties and seems to facilitate channel opening, as assessed by menthol-induced response. Overexpression leads to a reduction in both the speed and directionality of migration of prostate cancer cells. | 25559186 |
| 2015-03-21 11:42:00 | Report novel TRP channel-associated factors that modulate TRPM8 activity. | 25559186 |
| Type | IDs |
|---|---|
| Synonymous | FAM115A |
| Gene |
UniProtKB-ID:
TCAF1_HUMAN,
B4DST7_HUMAN
UniprotKB:
Q9Y4C2,
B4DST7
UniParc:
UPI00017A7C8D,
UPI000013CEDB,
UPI00001AE790
EMBL:
AK291605,
AB018281,
BC000609,
AC099548,
AK299911
Ensembl:
ENSG00000198420
KO:
hsa:9747
|
| Nucleutide sequences |
EMBL-CDS:
BAA34458.2,
AAQ96853.1,
AAQ96852.1,
AAH00609.1,
BAF84294.1,
BAG61749.1
Ensembl_TRS:
ENST00000479870,
ENST00000355951
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000419235,
ENSP00000348220
RefSeq:
XP_005250132.1,
XP_005250133.1,
XP_006716255.1,
NP_055534.2,
NP_001193867.2,
XP_005250134.1,
NP_001193870.1,
XP_006716254.1,
XP_016868322.1,
XP_005250131.1
|
| Others |
UniRef100:
UniRef100_B4DST7,
UniRef100_Q9Y4C2
UniRef90:
UniRef90_Q9Y4C2,
UniRef90_A0A250Y1Z6
UniRef50:
UniRef50_A0A250Y1Z6,
UniRef50_Q9Y4C2
UniGene:
Hs.735149,
Hs.744048
CCDS:
CCDS56514.1,
CCDS5886.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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