| Type | Description |
|---|---|
| Definition | extra spindle pole bodies like 1, separase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 12:45:00 | human cells that enter mitosis with already active separase rapidly undergo death in mitosis owing to direct cleavage of anti-apoptotic MCL1 and BCL-XL by separase; separase-triggered apoptosis enforces minimal length of mitosis | 32322059 |
| 2020-06-06 12:45:00 | results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the spindle assembly checkpoint | 32322060 |
| 2020-05-16 10:14:00 | data suggests an association between high separase activity, residual BCR-ABL1 gene expression, and enhanced proliferative capacity in hematopoietic cells within the leukemic niche of TKI-treated chronic phase CML. | 32253454 |
| 2020-03-14 10:50:00 | LPE motif on the Scc1 substrate is required for rapid and specific cleavage by separase. | 31729382 |
| 2019-10-05 10:44:00 | Thus, tethering of separase to DSBs and confined cohesin cleavage promote DSB repair in G2 cells. Importantly, this conserved interphase function of separase protects mammalian cells from oncogenic transformation. | 30305303 |
| Type | IDs |
|---|---|
| Synonymous | ESP1, SEPA |
| Gene |
UniProtKB-ID:
ESPL1_HUMAN
UniprotKB:
Q14674
UniParc:
UPI000013CF9C,
UPI00003668C3
EMBL:
AY455930,
AC073611,
D79987,
AC021072
Ensembl:
ENSG00000135476
KO:
hsa:9700
|
| Nucleutide sequences |
EMBL-CDS:
BAA11482.2,
AAR18247.1
Ensembl_TRS:
ENST00000257934
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000257934
RefSeq:
NP_036423.4,
XP_016875742.1,
XP_006719768.1,
XP_011537327.1,
XP_011537326.1
|
| Others |
UniRef100:
UniRef100_Q14674
UniRef90:
UniRef90_Q14674
UniRef50:
UniRef50_Q14674
UniGene:
Hs.153479
CCDS:
CCDS8852.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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