| Type | Description |
|---|---|
| Definition | ER degradation enhancing alpha-mannosidase like protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:23:00 | EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired. | 32423001 |
| 2019-06-08 10:21:00 | A somatic variant of EDEM1 (N198I) alters ATF6 signaling and provides a selective advantage to the transforming cells and results in hepatocellular carcinoma. | 30281916 |
| 2019-03-02 12:53:00 | EDEM1 employs different binding modalities to interact with ERAD clients and ER quality control machinery partners and some of these properties are shared with its homologues EDEM2 and EDEM3. | 30021839 |
| 2015-04-18 12:11:00 | EDEM1 colocalizes with the selective autophagy cargo receptors p62/SQSTM1, neighbor of BRCA1 gene 1 (NBR1) and autophagy-linked FYVE (Alfy) protein, and becomes engulfed by autophagic isolation membranes. | 24664425 |
| 2015-02-14 13:18:00 | Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. | 25132672 |
| Type | IDs |
|---|---|
| Synonymous | EDEM |
| Gene |
UniProtKB-ID:
EDEM1_HUMAN,
A0A024R2D5_HUMAN
UniprotKB:
Q92611,
A0A024R2D5
UniParc:
UPI000020AA4A,
UPI0000040633
EMBL:
AC026202,
AK292643,
D86967,
AK302065,
CH471055,
BC019088
Ensembl:
ENSG00000134109
KO:
hsa:9695
|
| Nucleutide sequences |
EMBL-CDS:
BAG63455.1,
BAF85332.1,
EAW63925.1,
BAA13203.2,
AAH19088.1,
EAW63926.1
Gene_ORFName:
hCG_21730
Ensembl_TRS:
ENST00000256497,
ENST00000445686
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256497,
ENSP00000394099
RefSeq:
NP_055489.1,
XP_011532574.1,
XP_011532573.1
|
| Others |
UniRef100:
UniRef100_Q92611
UniRef90:
UniRef90_Q92611
UniRef50:
UniRef50_Q92611
UniGene:
Hs.224616
CCDS:
CCDS33686.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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