Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Science     David E Gordon , Joseph Hiatt , Mehdi Bouhaddou , Veronica V Rezelj , Svenja Ulferts , Hannes Braberg , Alexander S Jureka , Kirsten Obernier , Jeffrey Z Guo , Jyoti Batra , Robyn M Kaake , Andrew R Weckstein , Tristan W Owens , Meghna Gupta , Sergei Pourmal , Erron W Titus , Merve Cakir , Margaret Soucheray , Michael McGregor , Zeynep Cakir , Gwendolyn Jang , Matthew J O'Meara , Tia A Tummino , Ziyang Zhang , Helene Foussard , Ajda Rojc , Yuan Zhou , Dmitry Kuchenov , Ruth Hüttenhain , Jiewei Xu , Manon Eckhardt , Danielle L Swaney , Jacqueline M Fabius , Manisha Ummadi , Beril Tutuncuoglu , Ujjwal Rathore , Maya Modak , Paige Haas , Kelsey M Haas , Zun Zar Chi Naing , Ernst H Pulido , Ying Shi , Inigo Barrio-Hernandez , Danish Memon , Eirini Petsalaki , Alistair Dunham , Miguel Correa Marrero , David Burke , Cassandra Koh , Thomas Vallet , Jesus A Silvas , Caleigh M Azumaya , Christian Billesbølle , Axel F Brilot , Melody G Campbell , Amy Diallo , Miles Sasha Dickinson , Devan Diwanji , Nadia Herrera , Nick Hoppe , Huong T Kratochvil , Yanxin Liu , Gregory E Merz , Michelle Moritz , Henry C Nguyen , Carlos Nowotny , Cristina Puchades , Alexandrea N Rizo , Ursula Schulze-Gahmen , Amber M Smith , Ming Sun , Iris D Young , Jianhua Zhao , Daniel Asarnow , Justin Biel , Alisa Bowen , Julian R Braxton , Jen Chen , Cynthia M Chio , Un Seng Chio , Ishan Deshpande , Loan Doan , Bryan Faust , Sebastian Flores , Mingliang Jin , Kate Kim , Victor L Lam , Fei Li , Junrui Li , Yen-Li Li , Yang Li , Xi Liu , Megan Lo , Kyle E Lopez , Arthur A Melo , Frank R Moss , Phuong Nguyen , Joana Paulino , Komal Ishwar Pawar , Jessica K Peters , Thomas H Pospiech , Maliheh Safari , Smriti Sangwan , Kaitlin Schaefer , Paul V Thomas , Aye C Thwin , Raphael Trenker , Eric Tse , Tsz Kin Martin Tsui , Feng Wang , Natalie Whitis , Zanlin Yu , Kaihua Zhang , Yang Zhang , Fengbo Zhou , Daniel Saltzberg , QCRG Structural Biology Consortium , Anthony J Hodder , Amber S Shun-Shion , Daniel M Williams , Kris M White , Romel Rosales , Thomas Kehrer , Lisa Miorin , Elena Moreno , Arvind H Patel , Suzannah Rihn , Mir M Khalid , Albert Vallejo-Gracia , Parinaz Fozouni , Camille R Simoneau , Theodore L Roth , David Wu , Mohd Anisul Karim , Maya Ghoussaini , Ian Dunham , Francesco Berardi , Sebastian Weigang , Maxime Chazal , Jisoo Park , James Logue , Marisa McGrath , Stuart Weston , Robert Haupt , C James Hastie , Matthew Elliott , Fiona Brown , Kerry A Burness , Elaine Reid , Mark Dorward , Clare Johnson , Stuart G Wilkinson , Anna Geyer , Daniel M Giesel , Carla Baillie , Samantha Raggett , Hannah Leech , Rachel Toth , Nicola Goodman , Kathleen C Keough , Abigail L Lind , Zoonomia Consortium , Reyna J Klesh , Kafi R Hemphill , Jared Carlson-Stevermer , Jennifer Oki , Kevin Holden , Travis Maures , Katherine S Pollard , Andrej Sali , David A Agard , Yifan Cheng , James S Fraser , Adam Frost , Natalia Jura , Tanja Kortemme , Aashish Manglik , Daniel R Southworth , Robert M Stroud , Dario R Alessi , Paul Davies , Matthew B Frieman , Trey Ideker , Carmen Abate , Nolwenn Jouvenet , Georg Kochs , Brian Shoichet , Melanie Ott , Massimo Palmarini , Kevan M Shokat , Adolfo García-Sastre , Jeremy A Rassen , Robert Grosse , Oren S Rosenberg , Kliment A Verba , Christopher F Basler , Marco Vignuzzi , Andrew A Peden , Pedro Beltrao , Nevan J Krogan

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

Nat Commun     Dick J H van den Boomen , Agata Sienkiewicz , Ilana Berlin , Marlieke L M Jongsma , Daphne M van Elsland , J Paul Luzio , Jacques J C Neefjes , Paul J Lehner

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

Mol Cell Proteomics     Molly M Hannigan , Alyson M Hoffman , J Will Thompson , Tianli Zheng , Christopher V Nicchitta

A High-Density Human Mitochondrial Proximity Interaction Network.

Cell Metab     Hana Antonicka , Zhen-Yuan Lin , Alexandre Janer , Mari J Aaltonen , Woranontee Weraarpachai , Anne-Claude Gingras , Eric A Shoubridge

Structural basis for membrane insertion by the human ER membrane protein complex.

Science     Tino Pleiner , Giovani Pinton Tomaleri , Kurt Januszyk , Alison J Inglis , Masami Hazu , Rebecca M Voorhees

A reference map of the human binary protein interactome.

Nature     Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat Taşan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D.

Nat Commun     Susan A Kennedy , Mohamed-Ali Jarboui , Sriganesh Srihari , Cinzia Raso , Kenneth Bryan , Layal Dernayka , Theodosia Charitou , Manuel Bernal-Llinares , Carlos Herrera-Montavez , Aleksandar Krstic , David Matallanas , Max Kotlyar , Igor Jurisica , Jasna Curak , Victoria Wong , Igor Stagljar , Thierry LeBihan , Lisa Imrie , Priyanka Pillai , Miriam A Lynn , Erik Fasterius , Cristina Al-Khalili Szigyarto , James Breen , Christina Kiel , Luis Serrano , Nora Rauch , Oleksii Rukhlenko , Boris N Kholodenko , Luis F Iglesias-Martinez , Colm J Ryan , Ruth Pilkington , Patrizia Cammareri , Owen Sansom , Steven Shave , Manfred Auer , Nicola Horn , Franziska Klose , Marius Ueffing , Karsten Boldt , David J Lynn , Walter Kolch

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

Biochem Biophys Res Commun     Takumi Okamoto , Yan Wu , Koji Matsuhisa , Atsushi Saito , Fumika Sakaue , Kazunori Imaizumi , Masayuki Kaneko

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

iScience     Mohamed Taha Moutaoufik , Ramy Malty , Shahreen Amin , Qingzhou Zhang , Sadhna Phanse , Alla Gagarinova , Mara Zilocchi , Larissa Hoell , Zoran Minic , Maria Gagarinova , Hiroyuki Aoki , Jocelyn Stockwell , Matthew Jessulat , Florian Goebels , Kirsten Broderick , Nichollas E Scott , James Vlasblom , Gabriel Musso , Bhanu Prasad , Eleonora Lamantea , Barbara Garavaglia , Alex Rajput , Kei Murayama , Yasushi Okazaki , Leonard J Foster , Gary D Bader , Francisco S Cayabyab , Mohan Babu

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.

J Biol Chem     Brianna E Talbot , David H Vandorpe , Brian R Stotter , Seth L Alper , Johannes S Schlondorff