| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:54:00 | Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2. | 31171376 |
| 2015-11-14 11:35:00 | Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex. | 25189171 |
| 2015-06-20 11:15:00 | local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid. | 24858808 |
| 2015-02-14 12:06:00 | SCF(FBXW11) bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1 | 25332235 |
| 2014-09-27 12:06:00 | JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. | 23885123 |
| Type | IDs |
|---|---|
| Synonymous | CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, RAGEF, Rap-GEP, nRap GEP |
| Gene |
UniProtKB-ID:
RPGF2_HUMAN
UniprotKB:
Q9Y4G8
UniParc:
UPI0000033783
EMBL:
AB002311,
CH471056
Ensembl:
ENSG00000109756
KO:
hsa:9693
|
| Nucleutide sequences |
EMBL-CDS:
EAX04847.1,
BAA20772.2,
EAX04848.1
Ensembl_TRS:
ENST00000264431
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264431
RefSeq:
XP_006714483.1,
XP_006714485.1,
NP_001338656.1,
XP_011530727.1,
NP_001338653.1,
XP_005263416.1,
NP_001338657.1,
XP_005263418.1,
XP_016864345.1,
XP_011530728.1,
NP_055062.1,
XP_005263417.1,
XP_024310054.1,
XP_024310055.1,
NP_001338654.1,
XP_005263415.1,
NP_001338655.1
|
| Others |
UniRef100:
UniRef100_Q9Y4G8
UniRef90:
UniRef90_Q9Y4G8
UniRef50:
UniRef50_Q9Y4G8
UniGene:
Hs.744884
CCDS:
CCDS43277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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