| Type | Description |
|---|---|
| Definition | vestigial like family member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 10:54:00 | VGLL4 interacts with to function as a tumor suppressor in triple-negative breast cancer | 31748508 |
| 2020-01-04 10:25:00 | Identification of VGLL4 as an important regulator of PD-L1 expression and a central role of VGLL4 and YAP in the regulation of tumor immunity. | 30396996 |
| 2019-09-21 10:25:00 | our RNA-seq analyses suggest that while the stimulatory effects of CytoD on osteogenesis are pleiotropic and depend on the biological state of the cell type, a small group of genes including VGLL4 may contribute to MSC commitment toward the bone lineage. | 29882479 |
| 2019-03-02 11:45:00 | Data report that VGLL4 functions as a suppressor of breast tumor (BC) growth and progression. Its low expression correlated with a poor prognosis. Its ectopic expression in BC cell lines reduced cell proliferation, migration, and tumor formation in xenograft mouse model. VGLL4 interacts with TEAD1 via its second TEAD-interacting domain, antagonizing YAP-dependent tumor growth. | 28733631 |
| 2018-12-22 11:35:00 | Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4. | 28051067 |
| Type | IDs |
|---|---|
| Synonymous | VGL-4 |
| Gene |
UniProtKB-ID:
VGLL4_HUMAN,
A0A075B6E4_HUMAN,
G5E9M9_HUMAN,
G5E9M7_HUMAN,
A0A0A6YYI5_HUMAN
UniprotKB:
Q14135,
A0A075B6E4,
G5E9M9,
G5E9M7,
A0A0A6YYI5
UniParc:
UPI000020AB43,
UPI0000EE2AB6,
UPI000020AB46,
UPI00003BF78D,
UPI000013FB70,
UPI00015D3867,
UPI000013FB7A,
UPI000006D3C1,
UPI000013D995,
UPI00001BD8F1
EMBL:
BC003038,
KF457588,
BC001514,
AC022001,
CH471055,
AK130542,
DA770257,
D50911,
AK308761,
KF457586,
AK300344,
AC090939,
AK307708
Ensembl:
ENSG00000144560
KO:
hsa:9686
|
| Nucleutide sequences |
EMBL-CDS:
AAH01514.2,
BAG62089.1,
BAC85375.1,
BAA09470.3,
EAW64104.1,
AAH03038.1,
EAW64102.1,
EAW64101.1,
EAW64100.1,
EAW64103.1,
EAW64099.1
Gene_ORFName:
hCG_1777277,
hCG_1777277,
hCG_1777277
Ensembl_TRS:
ENST00000424529,
ENST00000451674,
ENST00000273038,
ENST00000413604,
ENST00000430365,
ENST00000426568
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000416615,
ENSP00000402878,
ENSP00000273038,
ENSP00000404624,
ENSP00000404251,
ENSP00000413030
RefSeq:
XP_016863031.1,
NP_001121693.1,
NP_001271320.1,
XP_011532571.1,
XP_024309604.1,
XP_024309605.1,
NP_001121691.1,
XP_016863030.1,
NP_001271319.1,
NP_001121692.1,
XP_024309603.1,
NP_055482.2,
XP_011532569.1
|
| Others |
UniRef100:
UniRef100_G5E9M7,
UniRef100_Q14135,
UniRef100_A0A075B6E4,
UniRef100_A0A0A6YYI5
UniRef90:
UniRef90_G5E9M7,
UniRef90_Q14135
UniRef50:
UniRef50_G3TIA6,
UniRef50_Q14135
UniGene:
Hs.740389
CCDS:
CCDS46755.1,
CCDS2606.1,
CCDS46756.1,
CCDS46754.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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