| Type | Description |
|---|---|
| Definition | mediator of DNA damage checkpoint 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:58:00 | MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells. | 32160908 |
| 2020-07-04 10:20:00 | MDC1 plays a role in tumorigenesis of oral squamous cell carcinoma | 31786813 |
| 2020-03-14 10:50:00 | The PST-repeat region directly interacts with chromatin via the nucleosome acidic patch and mediates DNA damage-independent association of MDC1 with chromatin. | 31729360 |
| 2019-10-26 11:31:00 | we find that TOPBP1 forms filamentous structures capable of bridging MDC1 foci in mitosis, indicating that MDC1-TOPBP1 complexes tether DSBs until repair is reactivated in the following G1 phase. Thus, we reveal an important, hitherto-unnoticed cooperation between MDC1 and TOPBP1 in maintaining genome stability during cell division | 30898438 |
| 2019-10-12 12:35:00 | CTD Tyr1-phosphorylated RNAPII (CTD Y1P) synthetizes strand-specific, damage-responsive transcripts (DARTs), which trigger formation of double-stranded (ds)RNA intermediates via DNA-RNA hybrid intermediates to promote recruitment of p53-binding protein 1 (53BP1) and Mediator of DNA damage checkpoint 1 (MDC1) to endogenous DSBs. | 30668775 |
| Type | IDs |
|---|---|
| Synonymous | NFBD1 |
| Gene |
UniProtKB-ID:
MDC1_HUMAN,
A0A1U9XBC1_HUMAN,
A1Z5I9_HUMAN
UniprotKB:
Q14676,
A0A1U9XBC1,
A1Z5I9
UniParc:
UPI0000ED6214,
UPI000175027D,
UPI000175027C,
UPI000053E937,
UPI00001AF453
EMBL:
CR749828,
KY500451,
BA000025,
BC152556,
BC110645,
KY500445,
BX927283,
BX248307,
D79992,
AL662797,
CR788240,
AB103605,
AL662848,
CR759873,
CR936878,
EF177823,
AB202097,
KY500447,
AB088099,
AL845353,
CH471081
Ensembl:
ENSG00000234012,
ENSG00000237095,
ENSG00000224587,
ENSG00000231135,
ENSG00000137337,
ENSG00000225589,
ENSG00000228575,
ENSG00000206481
KO:
hsa:9656
|
| Nucleutide sequences |
EMBL-CDS:
BAF31266.1,
BAB63322.1,
CAH18685.1,
BAA11487.2,
AAI10646.1,
BAE78617.1,
EAX03321.1,
AAI52557.1,
BAC54931.1,
AQY78598.1,
AQY78604.1,
AQY78600.1,
ABM47421.1
Ensembl_TRS:
ENST00000420019,
ENST00000427406,
ENST00000449153,
ENST00000420320,
ENST00000440369,
ENST00000435664,
ENST00000376406,
ENST00000383566
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365588,
ENSP00000409167,
ENSP00000415212,
ENSP00000373060,
ENSP00000387429,
ENSP00000396484,
ENSP00000416511,
ENSP00000404318
RefSeq:
XP_016867010.1,
XP_016867008.1,
XP_005249550.1,
XP_011513305.1,
XP_005249554.1,
XP_005249555.1,
XP_011513303.1,
XP_011513306.1,
NP_055456.2,
XP_005249549.1,
XP_005249551.1,
XP_016867011.1,
XP_016867009.1
|
| Others |
UniRef100:
UniRef100_A0A2J8SJG3,
UniRef100_Q14676
UniRef90:
UniRef90_Q14676,
UniRef90_Q14676-2
UniRef50:
UniRef50_Q14676
UniGene:
Hs.653495
CCDS:
CCDS34384.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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