| Type | Description |
|---|---|
| Definition | SH3 and PX domains 2A |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:44:00 | Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia. | 32673397 |
| 2020-05-02 10:46:00 | The present GWAS was the first to implicate SH3PXD2A in non-syndromic cleft formation in humans. In summary, although performed in a relatively small sample, the present GWAS generated novel insights into nsCL/P etiology. | 31817908 |
| 2020-04-18 10:19:00 | in the invadopodia-competent Src-3T3 model system, mutations in any one of the first three SH3 domains had a dominant negative effect that largely eliminated the presence of invadopodia, inhibited gelatin degradation activity, and redistributed both Src, cortactin, and Tks5 to what are likely endosomal compartments | 31999741 |
| 2019-02-23 10:51:00 | TKS5 is expressed in human pancreatic adenocarcinoma lines. TKS5 localizes at mature and immature invadopodia in pancreatic cancer cells. Pancreatic cancer cells depend on TKS5 for invadopodia formation and function. | 30439350 |
| 2018-03-03 11:23:00 | Our results suggest that dissociation between XB130 and Tks5 may facilitate lateral cell migration via XB130/Rac1, and vertical cell migration via Tks5/Cdc42. These molecular mechanisms will help our understanding of airway epithelial repair and regeneration. | 27835612 |
| Type | IDs |
|---|---|
| Synonymous | FISH, SH3MD1, TKS5 |
| Gene |
UniProtKB-ID:
SPD2A_HUMAN,
B3KPL1_HUMAN
UniprotKB:
Q5TCZ1,
B3KPL1
UniParc:
UPI000006F165,
UPI000046FCE8,
UPI00001A833A,
UPI000041B175
EMBL:
AL133355,
AB007878,
AL121929,
CH471066,
AK056469
Ensembl:
ENSG00000107957
KO:
hsa:9644
|
| Nucleutide sequences |
EMBL-CDS:
BAA24848.2,
EAW49623.1,
EAW49624.1,
BAG51723.1
Ensembl_TRS:
ENST00000355946,
ENST00000369774
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348215,
ENSP00000358789
RefSeq:
NP_055446.2,
NP_001352008.1
|
| Others |
UniRef100:
UniRef100_Q5TCZ1,
UniRef100_B3KPL1
UniRef90:
UniRef90_Q5TCZ1
UniRef50:
UniRef50_Q5TCZ1
UniGene:
Hs.678727
CCDS:
CCDS31278.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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