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9639 ARHGEF10

9639

ARHGEF10

Rho guanine nucleotide exchange factor 10

protein-coding

Homo sapiens

基因描述

Type Description
Definition Rho guanine nucleotide exchange factor 10

研究结论

Date Results Publications
2020-06-20 12:02:00 this genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption 31372216
2020-04-18 11:52:00 Treatment of ARHGEF10-depleted cells with the inhibitor dasatinib reduced levels of phospho Src kinase and attenuated motility and invasion in vitro. Together, our data indicate that ARHGEF10 may function as a tumor suppressor in Pancreatic ductal adenocarcinoma (PDAC). 31477830
2020-04-11 10:44:00 it was suggested that ARHGEF10 is involved in the regulation of Rab6A and Rab8A localization and invasion of breast carcinoma cells, in which Rab8 also acts via regulation of membrane trafficking. 28448737
2019-09-21 12:19:00 A single nucleotide polymorphisms (SNPs) associated with higher delta-6 desaturase (D6D) activity within the Rho guanine nucleotide exchange factor 10 (ARHGEF10) gene is potentially altering plasma triglyceride levels. 29246731
2017-08-05 11:22:00 Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. 27550519

名称对应

Type IDs
Synonymous GEF10, SNCV
Gene
UniProtKB-ID: ARHGA_HUMAN
UniprotKB: O15013
UniParc: UPI0000D89824, UPI0001E8F10E, UPI00005054FE, UPI0001E8F10F, UPI0000D89826
EMBL: AC019257, BC040474, AF009205, BC112926, CR749570, BC036809, AB002292
Ensembl: ENSG00000104728, ENSG00000274726
KO: hsa:9639
Nucleutide sequences
EMBL-CDS: BAA20754.2, AAB71662.1, AAH40474.1, CAH18365.1, AAI12927.1, AAH36809.1
Ensembl_TRS: ENST00000520359, ENST00000349830, ENST00000631758, ENST00000619613, ENST00000610399, ENST00000398564, ENST00000518288, ENST00000633616
Protein sequencees
Ensembl_PRO: ENSP00000488343, ENSP00000431012, ENSP00000488463, ENSP00000381571, ENSP00000481974, ENSP00000340297, ENSP00000427909, ENSP00000477988
RefSeq: XP_005266098.1, NP_001295082.1, XP_011533070.1, XP_011533072.1, XP_024303102.1, XP_011533069.1, NP_001295081.1, NP_055444.2, XP_016869492.1, XP_024303103.1
Others
UniRef100: UniRef100_O15013
UniRef90: UniRef90_O15013
UniRef50: UniRef50_O15013
UniGene: Hs.98594
CCDS: CCDS78296.1, CCDS78297.1, CCDS34794.1

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