RGS6 - regulator of G protein signaling 6-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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9628 RGS6

基因描述

Type	Description
Definition	regulator of G protein signaling 6

研究结论

Date	Results	Publications
2020-09-19 16:23:00	Age-dependent nigral dopaminergic neurodegeneration and alpha-synuclein accumulation in RGS6-deficient mice.	31120439
2018-04-28 10:11:00	the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo.	28731026
2017-10-21 10:28:00	study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6	28665981
2017-10-07 11:16:00	genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied.	28090039
2017-05-20 14:31:00	Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities.	26987813

名称对应

Type	IDs
Synonymous	GAP, HA117, S914
Gene	UniProtKB-ID: RGS6_HUMAN, B7Z2A0_HUMAN, B7Z2N1_HUMAN, Q2M3K2_HUMAN UniprotKB: P49758, B7Z2A0, B7Z2N1, Q2M3K2 UniParc: UPI0000EE33D8, UPI00001AADFF, UPI00001AADFE, UPI0000EE33D6, UPI00001AADFC, UPI0000EE33D7, UPI0000EE33D5, UPI000016981E, UPI0001914B26, UPI0000EE33D9, UPI00001698D1, UPI00001698D0, UPI00001AADFD, UPI0001914BD1, UPI0000EE33D4, UPI0000EE33D2, UPI0000EE33D3 EMBL: AY309097, AF465714, AF465717, BC113572, AF107620, AF465713, AK294895, CH471061, AC005993, AC005226, BC104877, KF455935, AF073921, AF465723, AC005157, AY309099, AF465718, AF465719, AF465720, AC005857, AF465716, AF156932, AK294486, AF465712, AF465727, AF465725, AF465721, AF107619, AF465711, AF465726, AF073920, AF465724, AF465722, AC005227, AC004828, AY309100, AC005477, AC005533, AY309098, AF465715, L40394 Ensembl: ENSG00000182732 KO: hsa:9628
Nucleutide sequences	EMBL-CDS: AAM03012.1, AAC83180.1, AAP74389.1, AAP74386.1, AAM03005.1, AAM03004.1, AAC26050.1, AAM03007.1, AAM03009.1, AAC26049.2, AAM03013.1, AAD34718.1, AAM03006.1, AAM03010.1, AAM03008.1, AAD05031.1, AAP74388.1, AAD40183.1, AAD34717.1, AAM03011.1, AAC42001.1, AAP74387.1, BAH11786.1, BAH11917.1, AAI04878.1, EAW81070.1, AAI13573.1 Gene_ORFName: hCG_20660 Ensembl_TRS: ENST00000556437, ENST00000406236, ENST00000355512, ENST00000555571, ENST00000404301, ENST00000553525, ENST00000554782, ENST00000553530, ENST00000554474, ENST00000407322, ENST00000402788
Protein sequencees	Ensembl_PRO: ENSP00000452331, ENSP00000384218, ENSP00000451855, ENSP00000451030, ENSP00000384612, ENSP00000385243, ENSP00000451912, ENSP00000347699, ENSP00000450936, ENSP00000450858, ENSP00000383953 RefSeq: XP_024305531.1, XP_024305527.1, NP_001357219.1, NP_001357220.1, NP_001357203.1, XP_016877309.1, XP_024305536.1, NP_001357211.1, XP_024305528.1, NP_001191350.1, NP_001357207.1, XP_016877319.1, NP_001357199.1, XP_011535709.1, NP_001357202.1, XP_024305532.1, NP_001191349.1, NP_001357201.1, XP_016877323.1, XP_024305544.1, NP_001357204.1, XP_016877321.1, NP_001357217.1, NP_001191346.1, NP_001357206.1, XP_016877316.1, XP_024305538.1, NP_001357221.1, NP_001191353.1, NP_004287.3, NP_001357218.1, NP_001191347.1, XP_016877317.1, NP_001357223.1, NP_001357213.1, XP_016877311.1, NP_001357208.1, NP_001357216.1, NP_001191345.1, XP_016877320.1, NP_001357212.1, XP_011535699.1, NP_001357200.1, NP_001191351.1, XP_016877322.1, NP_001191352.1, XP_024305542.1, NP_001357210.1, XP_016877315.1, NP_001357209.1, XP_024305529.1, NP_001191348.1, NP_001357215.1, XP_011535695.1, XP_016877314.1, NP_001357205.1, NP_001357222.1
Others	UniRef100: UniRef100_B7Z2A0, UniRef100_P49758 UniRef90: UniRef90_P49758 UniRef50: UniRef50_P49758 UniGene: Hs.509872 CCDS: CCDS55924.1, CCDS9808.1

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mRNA

Protein

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Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31120439	Age-dependent nigral dopaminergic neurodegeneration and Î±-synuclein accumulation in RGS6-deficient mice. JCI Insight Zili Luo , Katelin E Ahlers-Dannen , Mackenzie M Spicer , Jianqi Yang , Stephanie Alberico , Hanna E Stevens , Nandakumar S Narayanan , Rory A Fisher	2019-05-23	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
28731026	The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells. Cancer Gene Ther. Y X Guo , Y H Xu , G H Zheng , X Q Jin	2017-07-01	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
28090039	Interaction between the RGS6 gene and psychosocial stress on obesity-related traits. Endocr. J. Hyun-Jin Kim , Jin-Young Min , Kyoung-Bok Min	2017-03-31	-
28665981	HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6. PLoS ONE Shuangshuang Li , Xianqing Jin , Huan Wu , Yi Wang , Xiaoqing Li , Yuxia Guo , Shaoyan Liang	2017-01-01	-
26987813	Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at GÎ±i/o. Biochem. J. Jae-Pyo Jeon , Dhananjay P Thakur , Jin-Bin Tian , Insuk So , Michael X Zhu	2016-05-15	-
26653562	Prognostic value of regulator of G-protein signaling 6 in colorectal cancer. Biomed. Pharmacother. Yang Luo , Shao-Lan Qin , Min-Hao Yu , Yi-Fei Mu , Zheng-Shi Wang , Ming Zhong	2015-12-01	RGS6
25525169	RGS6: a novel gene associated with congenital cataract, mental retardation, and microcephaly in a Tunisian family. Invest. Ophthalmol. Vis. Sci. ManÃ¨l Chograni , Fowzan S Alkuraya , Faouzi Maazoul , Imen Lariani , Habiba Chaabouni-Bouhamed	2015-02-01	RGS6
26097584	Differential expression of FOXA1, DUSP6, and HA117 in colon segments of Hirschsprung's disease. Int J Clin Exp Pathol Yuanyuan Luo , Shuangshuang Li , Yinping Teng , Ning Wang , Li Li , Hang Liu , Xianqing Jin	2015-01-01	DUSP6, FOXA1

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