PB1 - polymerase PB1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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956534 PB1

基因描述

Type	Description
Definition	polymerase PB1

研究结论

Date	Results	Publications
2021-03-20 13:33:00	Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.	33087462
2021-03-06 13:27:00	A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.	33142846
2016-06-11 10:45:00	PB1-T296R substitution enhanced viral replication, polymerase activity and virulence.	26453960
2015-08-15 10:59:00	The ts-mutations in PB1, PB2, and PA genes are mostly involved in the modulation of the humoral immunity, but also have a moderate effect on the cellular adaptive immune response.	26182653
2014-06-21 12:20:00	The deletion of "UAAA" and "UAAACU" motifs in the PB1-3'-UTR significantly increased the protein expression.	23949786

名称对应

Type	IDs
Gene	UniProtKB-ID: RDRP_I34A1 UniprotKB: P03431 UniParc: UPI00000F638F EMBL: EF467819, AF389116, J02151, CY009450 KO: vg:956534
Nucleutide sequences	EMBL-CDS: AAM75156.1, AAA43581.1, ABD77683.1, ABO21706.1
Protein sequencees	RefSeq: NP_040985.1
Others	UniRef100: UniRef100_P03431 UniRef90: UniRef90_P03431 UniRef50: UniRef50_P03431

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mRNA

Protein

UniprotKB

Description

Refseq

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Ensembl: {{protein.nucleotideEnsembl}}

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Location

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Pubmed编号	文献信息	发表日期	相关基因
33087462	Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus. J Virol Qingxia Gao , Cha Yang , Caiyue Ren , Shishuo Zhang , Xiaochen Gao , Meilin Jin , Huanchun Chen , Wenjun Ma , Hongbo Zhou	2020-12-22	-
33142846	A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses Andrew Cox , Jordana Schmierer , Josephine D'Angelo , Andrew Smith , Dustyn Levenson , John Treanor , Baek Kim , Stephen Dewhurst	2020-10-31	-
26453960	A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice. Virology Zhijun Yu , Kaihui Cheng , Weiyang Sun , Xinghai Zhang , Yuanguo Li , Tiecheng Wang , Hualei Wang , Qianyi Zhang , Yue Xin , Li Xue , Kun Zhang , Jing Huang , Songtao Yang , Chuan Qin , Peter R Wilker , Donghui Yue , Hualan Chen , Yuwei Gao , Xianzhu Xia	2015-12-01	-
26182653	[Effect of Point Mutations in the Polymerase Genes of the Influenza A/PR/8/34 (H1N1) Virus on the Immune Response in a Mouse Model]. Vopr. Virusol. S A Kuznetsova , I N Isakova-Sivak , V A Kuznetcova , G D Petukhova , I V Losev , S A Donina , L G Rudenko , A N Naikhin	2015-01-01	PB1, PA, PB2
23949786	Impact of the segment-specific region of the 3'-untranslated region of the influenza A virus PB1 segment on protein expression. Virus Genes Jun Ma , Kang Liu , Chunyi Xue , Jianqiang Zhou , Shun Xu , Yida Ren , Jing Zheng , Yongchang Cao	2013-12-01	-
21837415	Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene. Arch. Virol. Wanyi Li , Xiaofan Yang , Yan Jiang , Baoning Wang , Yuan Yang , Zhonghua Jiang , Mingyuan Li	2011-11-01	PB1
19461581	Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. EMBO J Kanako Sugiyama , Eiji Obayashi , Atsushi Kawaguchi , Yukari Suzuki , Jeremy R H Tame , Kyosuke Nagata , Sam-Yong Park	2009-06-17	-
18660801	The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature Eiji Obayashi , Hisashi Yoshida , Fumihiro Kawai , Naoya Shibayama , Atsushi Kawaguchi , Kyosuke Nagata , Jeremy R H Tame , Sam-Yong Park	2008-08-28	PB1, PA
18182088	The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell. Microbiol. Igor Mazur , Darisuren Anhlan , David Mitzner , Ludmilla Wixler , Ulrich Schubert , Stephan Ludwig	2008-05-01	PB1-F2, PB1
6281731	Nucleotide sequence of human influenza A/PR/8/34 segment 2. Nucleic Acids Res. G Winter , S Fields	1982-03-25	-

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