| Type | Description |
|---|---|
| Definition | DNA mismatch repair protein MutL |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:22:00 | Responses of DNA Proteins to a Stable G-Quadruplex Embedded into a DNA Duplex Structure. | 33233554 |
| 2020-12-19 13:42:00 | Probing the DNA-binding center of the MutL protein from the Escherichia coli mismatch repair system via crosslinking and Forster resonance energy transfer. | 32061805 |
| 2020-03-28 11:16:00 | We further show that MutL is unable to activate the helicase activity of a chimeric UvrD containing the 2B subdomain of the structurally similar Rep helicase. Hence, MutL activation of the monomeric UvrD helicase is regulated specifically by its 2B subdomain. | 31363055 |
| 2020-03-07 11:08:00 | Observations are consistent with an exonuclease-independent MMR strand excision mechanism that relies on EcMutL-EcUvrD helicase-driven displacement of ssDNA segments between adjacent EcMutH-GATC incisions. | 31757945 |
| 2019-11-30 12:15:00 | In Bacillus subtilis, the interaction stimulates the endonuclease activity of MutL and it is critical for DNA mismatch repair. Conversely, disrupting the interaction between Escherichia coli MutL and the b-clamp only causes a mild mutator phenotype. Here, we determined the structures of the regulatory domains of E. coli and B. subtilis MutL bound to their respective b-clamps | 30916336 |
| Type | IDs |
|---|---|
| Synonymous | ECK4166 |
| Gene |
UniProtKB-ID:
MUTL_ECOLI
UniprotKB:
P23367
UniParc:
UPI00000016FD
EMBL:
Z11831,
M63655,
U00096,
L19346,
U14003,
AP009048
EnsemblGenome:
BAE78171,
b4170
KO:
eco:b4170,
ecj:JW4128
|
| Nucleutide sequences |
EMBL-CDS:
AAA24173.1,
BAE78171.1,
AAA20098.1,
AAC77127.1,
AAA97066.1,
CAA77850.1
EnsemblGenome_TRS:
AAC77127,
BAE78171
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC77127,
BAE78171
RefSeq:
NP_418591.1
|
| Others |
UniRef100:
UniRef100_C5A1G1
UniRef90:
UniRef90_B2TY45
UniRef50:
UniRef50_P14161
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员