| Type | Description |
|---|---|
| Definition | ribosome rescue factor HflX |
| Date | Results | Publications |
|---|---|---|
| 2019-05-25 10:46:00 | cryo-electron microscopy structure of the 50S-HflX complex in the presence of nonhydrolyzable analogues of ATP and guanosine triphosphate hints at a mode of action for the RNA helicase and suggests the linker helical domain may have a determinant role in RNA unwinding. Heat stress results in inactivation of the ribosome, and we show that HflX can restore heat-damaged ribosomes and improve cell survival. | 29930203 |
| 2019-02-02 10:47:00 | HflX protein protects Escherichia coli from manganese stress. | 30541959 |
| 2016-07-30 10:26:00 | Furthermore, we provide evidence that the bound state of the peptidyl transferase centre is able to regulate the GTPase activity of E-site bound HflX | 26733579 |
| 2016-03-12 10:18:00 | These results suggest a primary role of HflX in rescuing translationally arrested ribosomes under stress conditions. | 26458047 |
| Type | IDs |
|---|---|
| Synonymous | ECK4169, hflA, hslX |
| Gene |
UniProtKB-ID:
HFLX_ECOLI
UniprotKB:
P25519
UniParc:
UPI000012C692
EMBL:
D00743,
U00096,
U00005,
U14003,
AP009048
EnsemblGenome:
BAE78174,
b4173
KO:
ecj:JW4131,
eco:b4173
|
| Nucleutide sequences |
EMBL-CDS:
AAA97069.1,
AAC77130.1,
BAA00645.1,
BAE78174.1,
AAC43398.1
EnsemblGenome_TRS:
AAC77130,
BAE78174
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC77130,
BAE78174
RefSeq:
NP_418594.1
|
| Others |
UniRef100:
UniRef100_P25519
UniRef90:
UniRef90_P25519
UniRef50:
UniRef50_P25519
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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