alr - alanine racemase 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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948564 alr

基因描述

Type	Description
Definition	alanine racemase 1

研究结论

Date	Results	Publications
2017-05-20 14:17:00	a representative of fold type III, the Escherichia coli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL). Furthermore, E. coli CBL (fold type I) is a promiscuous alanine racemase. A single round of error-prone PCR and selection yielded variant ALR(Y274F), which catalyzes cystathionine beta-elimination with a near-native Michaelis constant (Km = 3.3 mm) but a poor turnover number (kcat approximate...	27474741
2010-01-21 00:00:00	In a mouse model of urinary tract infection, NU14 DeltaampG, NU14 DeltawaaL, and NU14 Deltaalr were attenuated compared to wild-type NU14 and showed reduced fitness in competition experiments.	18559433

名称对应

Type	IDs
Synonymous	ECK4045, alr5
Gene	UniProtKB-ID: ALR1_ECOLI UniprotKB: P0A6B4 UniParc: UPI00001258C2 EMBL: M12047, U00096, AP009048, U00006, K01174 EnsemblGenome: BAE78055, b4053 KO: ecj:JW4013, eco:b4053
Nucleutide sequences	EMBL-CDS: AAC77023.1, AAC43147.1, BAE78055.1 EnsemblGenome_TRS: AAC77023, BAE78055
Protein sequencees	EnsemblGenome_PRO: BAE78055, AAC77023 RefSeq: NP_418477.1
Others	UniRef100: UniRef100_P0A6B4 UniRef90: UniRef90_P0A6B4 UniRef50: UniRef50_P0A6B4

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
27474741	Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J Biol Chem Valerie W C Soo , Yuliana Yosaatmadja , Christopher J Squire , Wayne M Patrick	2016-09-16	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
19748470	A liquid chromatography-tandem mass spectrometry assay for Marfey's derivatives of L-Ala, D-Ala, and D-Ala-D-Ala: application to the in vivo confirmation of alanine racemase as the target of cycloserine in Escherichia coli. Anal. Biochem. Darshan Jamindar , William G Gutheil	2010-01-01	alr
18559433	Molecular basis of uropathogenic Escherichia coli evasion of the innate immune response in the bladder. Infect Immun Benjamin K Billips , Anthony J Schaeffer , David J Klumpp	2008-09-01	-
18434499	Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis. Protein Sci. Dalei Wu , Tiancen Hu , Liang Zhang , Jing Chen , Jiamu Du , Jianping Ding , Hualiang Jiang , Xu Shen	2008-06-01	alr
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
16243272	Directed evolution of bacterial alanine racemases with higher expression level. J. Biosci. Bioeng. Jiansong Ju , Haruo Misono , Kouhei Ohnishi	2005-09-01	alr
15796715	A novel assay method for an amino acid racemase reaction based on circular dichroism. Biochem. J. Masafumi Noda , Yasuyuki Matoba , Takanori Kumagai , Masanori Sugiyama	2005-07-15	alr
12715876	N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. J. Antibiot. Myoung Goo Kim , Ulrich Strych , Kurt Krause , Michael Benedik , Harold Kohn	2003-02-01	-

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