| Type | Description |
|---|---|
| Definition | DNA-binding transcriptional repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA |
| Date | Results | Publications |
|---|---|---|
| 2017-08-26 11:45:00 | A conserved regulatory mechanism in bifunctional biotin protein ligases BirA has been demonstrated for three bacterial strains. | 28466579 |
| 2016-03-26 10:59:00 | BirA signals to the global regulator Fur, which in turn activates LEE (locus of enterocyte effacement) genes to promote EHEC adherence in the low-biotin large intestine. | 25791315 |
| 2012-11-24 10:54:00 | work demonstrates that variable surface loops evolved to support BirA function in the homodimerization required for transcription repression by complementing the constant loops, which are constrained because of their essential role in posttranslational biotin addition | 22446587 |
| 2012-03-31 10:05:00 | BirA function entails extensive interactions among the three domains of the protein and show that normal ligase activity does not ensure normal DNA binding. | 22210766 |
| 2010-01-21 00:00:00 | Results describe the 2.8A resolution crystal structure of BirA in complex with the co-repressor analog biotinol-5'-AMP. | 16438984 |
| Type | IDs |
|---|---|
| Synonymous | ECK3965, bioR, dhbB |
| Gene |
UniProtKB-ID:
BIRA_ECOLI
UniprotKB:
P06709
UniParc:
UPI00001108FE
EMBL:
L14557,
M10123,
AP009048,
U00006,
M15820,
U00096
EnsemblGenome:
BAE77342,
b3973
KO:
eco:b3973,
ecj:JW3941
|
| Nucleutide sequences |
EMBL-CDS:
BAE77342.1,
AAA24186.1,
AAC76951.1,
AAA23520.1,
AAA23521.1,
AAC43075.1
EnsemblGenome_TRS:
AAC76951,
BAE77342
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE77342,
AAC76951
RefSeq:
NP_418404.1
|
| Others |
UniRef100:
UniRef100_P06709
UniRef90:
UniRef90_P06709
UniRef50:
UniRef50_P06709
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员