| Type | Description |
|---|---|
| Definition | multidrug/betaine/choline efflux transporter EmrE |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:38:00 | Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations. | 31637997 |
| 2019-10-19 11:08:00 | Few conserved amino acids in the small multidrug resistance transporter EmrE influence drug polyselectivity. | 29866867 |
| 2018-10-06 10:23:00 | Optimal positions of the peptide staple were determined using free-energy simulations of peptide binding to monomeric EmrE Three of the four top-scoring peptides selected for experimental testing resulted in significant inhibition of proton-driven ethidium efflux in live cells without nonspecific toxicity. The approach described here is expected to be of general use for the design of peptide therapeutics. | 30082384 |
| 2018-06-30 11:54:00 | Not only can EmrE export diverse drug substrates, it can couple antiport of a drug to either one or two protons, performing both electrogenic and electroneutral transport of a single substrate. | 29114048 |
| 2017-07-15 12:12:00 | In a practical application of the BLaTM system, the authors find that the antiparallel interaction of TMD4, the known dimerization domain of the dual-topology small multidrug transporter EmrE, is sequence-specific and much stronger than the parallel one. | 28432015 |
| Type | IDs |
|---|---|
| Synonymous | ECK0534, eb, mvrC |
| Gene |
UniProtKB-ID:
EMRE_ECOLI
UniprotKB:
P23895
UniParc:
UPI0000129EB1
EMBL:
M62732,
U00096,
AP009048,
Z11877,
U82598
EnsemblGenome:
b0543,
BAE76318
KO:
eco:b0543,
ecj:JW0531
|
| Nucleutide sequences |
EMBL-CDS:
CAA77936.1,
BAE76318.1,
AAA24190.1,
AAB40740.1,
AAC73644.1
EnsemblGenome_TRS:
AAC73644,
BAE76318
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE76318,
AAC73644
RefSeq:
NP_415075.1
|
| Others |
UniRef100:
UniRef100_P23895
UniRef90:
UniRef90_P23895
UniRef50:
UniRef50_P23895
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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