| Type | Description |
|---|---|
| Definition | DNA-binding transcriptional dual regulator CpxR |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 13:11:00 | Overall, these data demonstrate that NlpE acts as a sentinel for two important envelope biogenesis processes, namely, lipoprotein sorting and oxidative folding, and they further establish NlpE as a bona fide member of the CpxA-CpxR two-component system. | 30833359 |
| 2019-09-28 11:04:00 | Study found that the CpxRA system regulates the virulence properties of Avian pathogenic Escherichia coli. Adherence, invasiveness, motility, production of type 1 fimbriae and biofilm were negatively affected in the DeltacpxA mutant indicating that the CpxA is required for full manifestation of these phenotypes. | 30062827 |
| 2019-04-27 12:05:00 | The CpxAR system is widely considered to be responsible for sensing attachment, specifically to hydrophobic surfaces. Using both single-cell and population-level analyses, we confirm RcsCDB activation upon surface contact, but find that the CpxAR system is not activated, in contrast to what had earlier been reported. Thus, the role of CpxAR in surface sensing and initiation of biofilm formation should be reconsidered. | 30412611 |
| 2018-09-22 11:36:00 | Activation of CpxR upregulates the expression of genes encoding protein folding and chaperone factors and downregulates the expression of a number of envelope proteins/ | 29311237 |
| 2018-03-24 11:48:00 | X-ray structures of the CpxR reveals allosteric switching mechanism, according to which CpxR binding to one CpxA protomer triggers autophosphorylation in the second protomer. | 28552574 |
| Type | IDs |
|---|---|
| Synonymous | ECK3905, yiiA |
| Gene |
UniProtKB-ID:
CPXR_ECOLI
UniprotKB:
P0AE88
UniParc:
UPI000012833F
EMBL:
L19201,
U00096,
L14579,
M36795,
AP009048,
X13307
EnsemblGenome:
BAE77397,
b3912
KO:
eco:b3912,
ecj:JW3883
|
| Nucleutide sequences |
EMBL-CDS:
BAE77397.1,
AAA23599.1,
AAC36868.1,
AAB03045.1,
CAA31686.1,
AAC76894.1
EnsemblGenome_TRS:
BAE77397,
AAC76894
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC76894,
BAE77397
RefSeq:
NP_418348.1
|
| Others |
UniRef100:
UniRef100_P0AE89
UniRef90:
UniRef90_P0AE89
UniRef50:
UniRef50_P0AE89
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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