ilvC - ketol-acid reductoisomerase (NADP(+))-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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948286 ilvC

基因描述

Type	Description
Definition	ketol-acid reductoisomerase (NADP(+))

研究结论

Date	Results	Publications
2013-09-28 11:29:00	Key cofactor specificity determinants are identified and five enzymes constructed with reversed cofactor preference; additional directed evolution generated two enzymes with NADH-dependent catalytic efficiencies greater than wild-type enzymes with NADPH.	23776225
2013-02-02 11:22:00	Ultracentrifugation studies confirm that the enzyme exists as a tetramer in solution, and isothermal titration calorimetry shows that the binding of Mg(2+) decreases, while the binding of NADPH increases the structural rigidity of the enzyme.	23036858
2010-01-21 00:00:00	crystal structure of Escherichia coli ketol-acid reductoisomerase	15272168
2010-01-21 00:00:00	crystal structure of the E. coli enzyme at 2.6 A resolution, the first three-dimensional structure of any bacterial Class II KARI	16322583
2007-11-05 21:38:00	N-terminus verified by Edman degradation on mature peptide	9298646,9740056

名称对应

Type	IDs
Synonymous	ECK3766
Gene	UniProtKB-ID: ILVC_ECOLI UniprotKB: P05793 UniParc: UPI00001681EC EMBL: AP009048, M11689, U00096, M87049 EnsemblGenome: b3774, BAE77523 KO: ecj:JW3747, eco:b3774
Nucleutide sequences	EMBL-CDS: AAA24029.1, AAA67577.1, BAE77523.1, AAC76779.1 EnsemblGenome_TRS: AAC76779, BAE77523
Protein sequencees	EnsemblGenome_PRO: AAC76779, BAE77523 RefSeq: NP_418222.1
Others	UniRef100: UniRef100_C4ZZ44 UniRef90: UniRef90_P05989 UniRef50: UniRef50_P05989

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
27136273	Metal Ions Play an Essential Catalytic Role in the Mechanism of Ketol-Acid Reductoisomerase. Chemistry Sonya Tadrowski , Marcelo M Pedroso , Volker Sieber , James A Larrabee , Luke W Guddat , Gerhard Schenk	2016-05-23	-
24561554	The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. Seesandra V Rajagopala , Patricia Sikorski , Ashwani Kumar , Roberto Mosca , James Vlasblom , Roland Arnold , Jonathan Franca-Koh , Suman B Pakala , Sadhna Phanse , Arnaud Ceol , Roman HÃ¤user , Gabriella Siszler , Stefan Wuchty , Andrew Emili , Mohan Babu , Patrick Aloy , Rembert Pieper , Peter Uetz	2014-03-01	-
23776225	General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proc. Natl. Acad. Sci. U.S.A. Sabine Brinkmann-Chen , Tilman Flock , Jackson K B Cahn , Christopher D Snow , Eric M Brustad , John A McIntosh , Peter Meinhold , Liang Zhang , Frances H Arnold	2013-07-02	ilvC
23036858	Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J. Mol. Biol. Sze-Ho Wong , Thierry G A Lonhienne , Donald J Winzor , Gerhard Schenk , Luke W Guddat	2012-12-07	ilvC
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21515217	Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metab Eng Sabine Bastian , Xiang Liu , Joseph T Meyerowitz , Christopher D Snow , Mike M Y Chen , Frances H Arnold	2011-05-01	-
18304323	Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics Yasushi Ishihama , Thorsten Schmidt , Juri Rappsilber , Matthias Mann , F Ulrich Hartl , Michael J Kerner , Dmitrij Frishman	2008-01-01	-
17919278	Nitrosative stress treatment of E. coli targets distinct set of thiol-containing proteins. Mol Microbiol Nicolas Brandes , Andrea Rinck , Lars Ingo Leichert , Ursula Jakob	2007-11-01	-
17187058	Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol. Peng Lu , Christine Vogel , Rong Wang , Xin Yao , Edward M Marcotte	2007-01-01	sspA, talB, dnaK, dnaJ, rpsT, ileS, dapB, carB, ftsZ, murE, aceF, acpP, surA, secA, can, aceE, panB, argF, lpxA, dksA, lpd, erpA, skp, dapD, acnB, tsf, glnH, fabZ, metQ, accA, galM, sodB, panC, pyrH, codA, opgG, pepD, tauB, eno, proC, phoR, thiI, gpmA, leuC, tig, clpP, clpX, lon, adk, htpG, acrB, trpD, apt, ydgH, rplT, purK, ompT, thrC, ybeD, ahpC, purR, glf, serA, miaB, pgm, seqA, rfbB, iscR, asnB, mprA, fldA, fur, sucA, sucB, hisJ, glnS, sucC, sucD, gltA, bioB, pheT, bioD, metK, sdhA, ybiC, tolB, ybiT, ldtB, moeA, gsiB, yliE, ihfA, serS, pflB, serC, aroA, ihfB, rpsA, mukE
17012394	Experimental and computational assessment of conditionally essential genes in Escherichia coli. J. Bacteriol. Andrew R Joyce , Jennifer L Reed , Aprilfawn White , Robert Edwards , Andrei Osterman , Tomoya Baba , Hirotada Mori , Scott A Lesely , Bernhard Ã Palsson , Sanjay Agarwalla	2006-12-01	carB, leuB, cra, panB, pdxA, panC, proC, leuC, trpD, purK, fes, thrC, serA, gltA, nadA, trpC, serC, aroA, pyrD, leuD, panD, icd, trpB, cysB, pyrC, thrA, trpE, leuL, trpA, aroD, metC, pabB, proB, hisI, hisF, hisA, hisD, hisH, hisG, hisC, hisB, ubiG, proA, pdxB, purF, pdxH, aroC, cysK, ptsI, crr, cysU, cysP, cysA, purC, purM, guaB, iscS, glyA, purL, pdxJ, nadB, pheA, tyrA, pyrF, cysD, cysN, cysC, cysH, cysI, cysJ, argA, lysA, guaA, prfB, ubiH, leuA, thrB, folB, rpsU, folP, glmM, aroE, pabA, aroB, glpD, panM, cysE, pyrE, ilvB, atpA, atpG, atpC, atpF, atpB, atpH, ilvD, ilvC, ilvA, metR

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