| Type | Description |
|---|---|
| Definition | bifunctional (p)ppGpp synthase/hydrolase SpoT |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:57:00 | Study shows that the protein YtfK promotes SpoT-dependent accumulation of (p)ppGpp in E. coli and is required for activation of the stringent response during phosphate and fatty acid starvation. Results indicate that YtfK can interact with SpoT and propose that YtfK activates the stringent response by tilting the catalytic balance of SpoT toward (p)ppGpp synthesis. | 31848343 |
| 2019-06-08 12:34:00 | Deleting dksA, which encodes a regulator of the stringent response to nutrient starvation, decreases growth under glucose phosphate stress conditions. The stringent response alarmone regulator ppGpp (synthesized by RelA and SpoT) also contributes to recovery from glucose phosphate stress: as with dksA, mutating relA and spoT worsens the growth defect of an sgrS mutant during stress. | 28986375 |
| 2018-09-22 10:11:00 | Dephosphorylated HPr, but not phosphorylated HPr, of the phosphoenolpyruvate-dependent sugar phosphotransferase system could antagonize the stimulatory effect of Rsd on SpoT (p)ppGpp hydrolase activity. | 29915072 |
| 2015-12-05 11:19:00 | Mutations in relA, but not necessarily inactivating mutations, can be selected to compensate total SpoT function(s) loss in Escherichia coli. | 25188023 |
| 2012-04-07 11:28:00 | The results indicate that polyamine stimulation of synthesis of SpoT plays an important role for cell viability through stimulation of ppGpp synthesis by SpoT. | 22138225 |
| Type | IDs |
|---|---|
| Synonymous | ECK3640 |
| Gene |
UniProtKB-ID:
SPOT_ECOLI
UniprotKB:
P0AG24
UniParc:
UPI000003EB28
EMBL:
U00096,
AP009048,
M24503,
L10328
EnsemblGenome:
BAE77643,
b3650
KO:
ecj:JW3625,
eco:b3650
|
| Nucleutide sequences |
EMBL-CDS:
AAA62003.1,
BAE77643.1,
AAB00160.1,
AAC76674.1
EnsemblGenome_TRS:
BAE77643,
AAC76674
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE77643,
AAC76674
RefSeq:
NP_418107.1
|
| Others |
UniRef100:
UniRef100_P0AG25
UniRef90:
UniRef90_P0AG25
UniRef50:
UniRef50_Q9KNM2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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