| Type | Description |
|---|---|
| Definition | sensory histidine kinase ArcB |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study reports the in-situ structure of the E. coli AcrAB-TolC multidrug efflux pump obtained by electron cryo-tomography. The fully assembled efflux pump is observed in a closed state under conditions of antibiotic challenge and in an open state in the presence of AcrB inhibitor. Also study observed intermediate AcrAB complexes without TolC and discover that AcrA contacts the peptidoglycan layer of the periplasm. | 31201302 |
| 2018-04-28 10:18:00 | The authors observed that wild-type, DeltaarcA, and DeltaarcB had comparable initial NO* clearance times; however, the mutant cultures failed to exhibit [NO*] and [O2 ] oscillations. these results establish ArcAB as a TCS that influences NO* detoxification in E. coli within the physiologically-relevant microaerobic regime. | 28449226 |
| 2018-01-06 11:56:00 | The authors report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. | 28355133 |
| 2013-08-31 12:36:00 | Interactions between TolC and AcrAB are highly dynamic and only a small fraction of TolC is utilized to support efflux activities. | 23331412 |
| 2013-08-31 12:04:00 | Data show that the redox potential of ArcB is about -41 mV, and we demonstrate that the menaquinols are required for proper ArcB activation upon a shift from aerobic to anaerobic growth conditions. | 23645604 |
| Type | IDs |
|---|---|
| Synonymous | ECK3200 |
| Gene |
UniProtKB-ID:
ARCB_ECOLI
UniprotKB:
P0AEC3
UniParc:
UPI0000125D9E
EMBL:
AP009048,
U00096,
U18997,
X53315
EnsemblGenome:
BAE77254,
b3210
KO:
ecj:JW5536,
eco:b3210
|
| Nucleutide sequences |
EMBL-CDS:
CAA37397.1,
AAA58012.1,
AAT48172.1,
BAE77254.1
EnsemblGenome_TRS:
AAT48172,
BAE77254
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE77254,
AAT48172
RefSeq:
YP_026207.1
|
| Others |
UniRef100:
UniRef100_P0AEC3
UniRef90:
UniRef90_P0AEC3
UniRef50:
UniRef50_P0AEC3
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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