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947682 nusA

947682

nusA

transcription termination/antitermination protein NusA

protein-coding

Escherichia coli str. K-12 substr. MG1655

基因描述

Type Description
Definition transcription termination/antitermination protein NusA

研究结论

Date Results Publications
2021-02-06 13:51:00 Pre-termination Transcription Complex: Structure and Function. 33296676
2020-03-21 12:09:00 we show that a hairpin structure in the Escherichia coli thiamin pyrophosphate (TPP) thiC riboswitch is involved in transcriptional pausing and ligand sensitivity. Using in vitro transcription kinetic experiments, we show that all three major transcriptional pauses in the thiC riboswitch are affected by NusA, a transcriptional factor known to stimulate hairpin-stabilized pauses 31081713
2020-02-29 10:52:00 SuhB can be integrated into a Nus factor-, and optionally ribosomal protein S4-, containing antitermination complex halted at a ribosomal antitermination signal. Furthermore, SuhB specifically binds to the acidic repeat 2 domain of the multi-domain protein NusA, an interaction that may be involved in antitermination or posttranscriptional processes. 31127279
2019-01-05 10:23:00 The structures reveal four interactions between NusA and RNAP that suggest how NusA stimulates RNA folding, pausing, and termination. An asymmetric translocation intermediate of RNA and DNA converts the active site of the enzyme into an inactive state, providing a structural explanation for the inhibition of catalysis. 29499136
2017-06-10 10:19:00 The results suggest that interaction between NusA and NusG could play various regulatory roles during transcription, including recruitment of NusG to RNAP, resynchronization of transcription: translation coupling, and modulation of termination efficiency. 27174929

名称对应

Type IDs
Synonymous ECK3158
Gene
UniProtKB-ID: NUSA_ECOLI
UniprotKB: P0AFF6
UniParc: UPI0000130A38
EMBL: AP009048, U18997, U00096, X00513
EnsemblGenome: BAE77215, b3169
KO: ecj:JW3138, eco:b3169
Nucleutide sequences
EMBL-CDS: CAA25200.1, AAA57972.1, BAE77215.1, AAC76203.1
EnsemblGenome_TRS: AAC76203, BAE77215
Protein sequencees
EnsemblGenome_PRO: BAE77215, AAC76203
RefSeq: NP_417638.1
Others
UniRef100: UniRef100_P0AFF8
UniRef90: UniRef90_P37430
UniRef50: UniRef50_P37430

全选

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