| Type | Description |
|---|---|
| Definition | DNA topoisomerase IV subunit B |
| Date | Results | Publications |
|---|---|---|
| 2017-05-13 22:22:00 | a detailed characterization of a known potent inhibitor containing a 9H-pyrimido[4,5-b]indole scaffold against the N-terminal domain of the topoisomerase IV E subunit from Escherichia coli (eParE). Using a series of biophysical and biochemical experiments, it has been demonstrated that this inhibitor forms a tight complex with eParE. | 27365392 |
| 2017-05-13 20:28:00 | This interaction is modulated by MatP, a protein involved in the organization of the Ter macrodomain. These results show that Topo IV, XerCD/dif and MatP are part of a network dedicated to the final step of chromosome management during the cell cycle. | 27171414 |
| 2016-06-11 10:54:00 | Impairing the TopoIV-MukBEF interaction delays sister ter segregation in cells lacking MatP. | 26818444 |
| 2013-11-02 11:14:00 | The I529L SNP in parE was found in most, but not all, Escherichia coli ST131 isolates with fluoroquinolone and cephalosporin resistance. | 22991424 |
| 2010-01-21 00:00:00 | the E.coli topoisomerase IV conformation is altered upon enzyme binding to positively supercoiled DNA | 16684778 |
| Type | IDs |
|---|---|
| Synonymous | ECK3021, nfxD |
| Gene |
UniProtKB-ID:
PARE_ECOLI
UniprotKB:
P20083
UniParc:
UPI0000131347
EMBL:
L22026,
M58409,
U28377,
U00096,
AP009048
EnsemblGenome:
b3030,
BAE77086
KO:
eco:b3030,
ecj:JW2998
|
| Nucleutide sequences |
EMBL-CDS:
AAA69198.1,
AAA24298.1,
AAC76066.1,
AAC36841.1,
BAE77086.1
EnsemblGenome_TRS:
AAC76066,
BAE77086
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE77086,
AAC76066
RefSeq:
NP_417502.1
|
| Others |
UniRef100:
UniRef100_P20083
UniRef90:
UniRef90_P20083
UniRef50:
UniRef50_P20083
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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