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947369 prfB

947369

prfB

peptide chain release factor RF2

protein-coding

Escherichia coli str. K-12 substr. MG1655

基因描述

Type Description
Definition peptide chain release factor RF2

研究结论

Date Results Publications
2021-02-02 13:27:00 Molecular determinants of release factor 2 for ArfA-mediated ribosome rescue. 32727848
2020-02-08 11:30:00 In translation termination, the catalytic GGQ loop of RF2 is rearranged into a long beta-hairpin that plugs the peptide tunnel, biasing a nascent protein toward the ribosome exit. 31513010
2019-07-13 10:45:00 Study used time-resolved cryo-EM to visualize transient compact forms of RF1 and RF2 at 3.5 and 4 A resolution, respectively, in the codon-recognizing ribosome complex on the native pathway. About 25% of complexes have RFs in the compact state at 24 ms reaction time, and within 60 ms virtually all ribosome-bound RFs are transformed to their extended forms. 31189921
2019-04-20 11:30:00 Ribosome termination complexes that carry two factors, RF1-RF3 or RF2-RF3, are dynamic and fluctuate between non-rotated and rotated states, whereas each factor alone has its distinct signature on ribosome dynamics and conformation. 29889659
2018-05-12 10:57:00 both RF1 binding and RF2 binding are sufficient to shift the population of posthydrolysis ribosome complexes from primarily the rotated to the nonrotated state only when a cognate stop codon is present in the A-site. 29499110

名称对应

Type IDs
Synonymous ECK2886, supK
Gene
UniProtKB-ID: RF2_ECOLI
UniprotKB: P07012
UniParc: UPI000003EB03
EMBL: M11520, U00096, U28375, AP009048, J03795
EnsemblGenome: b2891, BAE76956
KO: eco:b2891, ecj:JW5847
Nucleutide sequences
EMBL-CDS: AAC75929.1, AAA24520.1, AAA83072.1, BAE76956.1, AAA23958.1
EnsemblGenome_TRS: BAE76956, AAC75929
Protein sequencees
EnsemblGenome_PRO: BAE76956, AAC75929
RefSeq: NP_417367.1
Others
UniRef100: UniRef100_C5A0G3
UniRef90: UniRef90_Q5PJG1
UniRef50: UniRef50_Q8ZHK4

全选

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