| Type | Description |
|---|---|
| Definition | ABC-type tripartite efflux pump membrane fusion protein |
| Date | Results | Publications |
|---|---|---|
| 2018-06-02 10:54:00 | A hexamer of the periplasmic protein MacA bridges between a TolC trimer in the outer membrane and a MacB dimer in the inner membrane, generating a quaternary structure with a central channel for substrate translocation. | 28504659 |
| 2017-11-25 14:14:00 | Structural comparison with the previously reported MacB periplasmic domain structure suggests a molecular mechanism for regulation of the activity of MacB via an interaction between the MacB periplasmic domain and MacA. Our results provide a better understanding of the tripartite pumps at the molecular level. | 29061301 |
| 2015-07-25 10:34:00 | Protoporphyrin (PPIX) efflux by the MacAB-TolC pump. | 25257218 |
| 2011-12-03 10:27:00 | We propose that MacA acts in transport by promoting MacB transition into the closed ATP-bound conformation and in this respect, is similar to the periplasmic solute-binding proteins. | 21696464 |
| 2010-05-31 12:08:00 | Mutational and biochemical analyses revealed that the conserved residues located at the tip region of the alpha-hairpin of MacA play an essential role in the binding of TolC. | 20307498 |
| Type | IDs |
|---|---|
| Synonymous | ECK0869, ybjY |
| Gene |
UniProtKB-ID:
MACA_ECOLI
UniprotKB:
P75830
UniParc:
UPI000012EB09
EMBL:
AP009048,
U00096,
AB071145
EnsemblGenome:
b0878,
BAA35597
KO:
ecj:JW0862,
eco:b0878
|
| Nucleutide sequences |
EMBL-CDS:
BAA35597.1,
BAB64541.1,
AAC73965.2
EnsemblGenome_TRS:
AAC73965,
BAA35597
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73965,
BAA35597
RefSeq:
NP_415399.4
|
| Others |
UniRef100:
UniRef100_P75830
UniRef90:
UniRef90_P75830
UniRef50:
UniRef50_P75830
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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