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947228 cas1

947228

cas1

multifunctional nuclease Cas1

protein-coding

Escherichia coli str. K-12 substr. MG1655

基因描述

Type Description
Definition multifunctional nuclease Cas1

研究结论

Date Results Publications
2019-06-29 12:10:00 A mini-integrase comprising the type V-C Cas1 protein alone catalyzes DNA integration with a preference for short (17- to 19-base-pair) DNA fragments in a two-protein-type V-C CRISPR system. 30709710
2018-02-10 10:46:00 These results explain how the Cas1-Cas2 CRISPR integrase recognizes a sequence-dependent DNA structure to ensure site-selective CRISPR array expansion during the initial step of bacterial adaptive immunity. 28729350
2017-08-26 10:29:00 in Escherichia coli cells undergoing primed adaptation, spacer-sized fragments of foreign DNA are associated with Cas1. 28204574
2017-08-12 12:34:00 to form a long-lived ternary complex containing Cas1-Cas2, the acceptor DNA must carry a CRISPR locus, and the protospacer must not contain 3-single-stranded overhangs longer than 5 bases. 28034956
2017-06-10 10:58:00 Asymmetric positioning of Cas1-Cas2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system. 27899566

名称对应

Type IDs
Synonymous ECK2750, ygbT
Gene
UniProtKB-ID: CAS1_ECOLI
UniprotKB: Q46896
UniParc: UPI000013B034
EMBL: U29579, AP009048, U00096
EnsemblGenome: BAE76832, b2755
KO: ecj:JW2725, eco:b2755
Nucleutide sequences
EMBL-CDS: BAE76832.1, AAC75797.1, AAA69265.1
EnsemblGenome_TRS: BAE76832, AAC75797
Protein sequencees
EnsemblGenome_PRO: AAC75797, BAE76832
RefSeq: NP_417235.1
Others
UniRef100: UniRef100_Q46896
UniRef90: UniRef90_Q46896
UniRef50: UniRef50_Q46896

全选

研究热度
该基因近6年没有文献发表
热点单位
排名 科研单位 文献
1

Howard Hughes Medical Institute

5
2

University of California

5
3

University of Toronto

3
4

Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

1
5

Institute for Research in Biomedicine (IRB Barcelona)

1
热点人员
排名 研究人员 文献
1

Jennifer A Doudna

6
2

Addison V Wright

3
3

Lucas B Harrington

2
4

M Riley

2
5

Edze R Westra

2
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