| Type | Description |
|---|---|
| Definition | alanine--tRNA ligase/DNA-binding transcriptional repressor |
| Date | Results | Publications |
|---|---|---|
| 2018-01-06 12:28:00 | Here, the authors show that DTD's active site architecture can efficiently edit mischarged Gly-tRNA(Ala) species four orders of magnitude more efficiently than even AlaRS, the only ubiquitous cellular checkpoint known for clearing the error. | 28362257 |
| 2012-01-07 11:34:00 | ATP binding to full length enzyme (ARS875) and to an N-terminal construct (ARS461) is endothermic (DeltaH = 3-4 kcal mol(-1)) with stoichiometries of 1:1 for ARS461 and 2:1 for full-length dimer. | 21985608 |
| 2010-01-21 00:00:00 | the editing site of alanyl-tRNA synthetase targets mischarged tRNA(Ala) using a structural motif unrelated to that for aminoacylation, so that, remarkably, two motifs in the same enzyme independently provide determinants for tRNA(Ala) recognition | 18172502 |
| 2010-01-21 00:00:00 | findings show that the C-Ala domain plays a key role in alanyl-tRNA synthetases (AlaRS) function; C-Ala forms an ancient single-stranded nucleic acid binding motif that promotes cooperative binding of both aminoacylation and editing domains to tRNA(Ala) | 19661429 |
| 2007-11-05 21:38:00 | N-terminus verified by Edman degradation on mature peptide | 7005898 |
| Type | IDs |
|---|---|
| Synonymous | ECK2692, act, ala-act, lovB |
| Gene |
UniProtKB-ID:
SYA_ECOLI
UniprotKB:
P00957
UniParc:
UPI0000136304
EMBL:
AP009048,
J01581,
U00096,
D44453,
L07596,
Z28405
EnsemblGenome:
BAA16559,
b2697
KO:
ecj:JW2667,
eco:b2697
|
| Nucleutide sequences |
EMBL-CDS:
AAA03208.1,
AAC75739.1,
BAA16559.1,
CAA82247.1,
AAA71918.1,
BAA21554.1
EnsemblGenome_TRS:
BAA16559,
AAC75739
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA16559,
AAC75739
RefSeq:
NP_417177.1
|
| Others |
UniRef100:
UniRef100_B1XCM5
UniRef90:
UniRef90_A7ZQC5
UniRef50:
UniRef50_A7ZQC5
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员