| Type | Description |
|---|---|
| Definition | elongation factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2015-12-05 11:10:00 | The last 44 C-terminal amino acids of EF4 form a sub-domain within the C-terminal domain that is important for GTP-dependent function on the ribosome. | 25712150 |
| 2015-06-27 10:16:00 | Thus, EF4 has two opposing functions-at low-to-moderate levels of stress, the protein is protective by allowing stress-paused translation to resume; at high-levels of stress, EF4 helps bacteria self-destruct. | 25491353 |
| 2013-07-06 10:02:00 | (review) EF4 triggers back-translocation of the elongating ribosome, causing the translation machinery to move one codon backwards along the mRNA. | 23662805 |
| 2011-05-07 11:24:00 | Elevated intracellular Mg(2+) concentrations or low temperature inhibit protein synthesis, probably because of formation of aberrant elongating ribosomal states. We suggest that EF4 binds to these stuck ribosomes and remobilizes them | 21300907 |
| 2010-04-12 12:23:00 | EF4-dependent back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex via a four-step kinetic scheme (i.e., POST-->I(1)-->I(2)-->I(3)-->PRE | 20045415 |
| Type | IDs |
|---|---|
| Synonymous | ECK2567 |
| Gene |
UniProtKB-ID:
LEPA_ECOLI
UniprotKB:
P60785
UniParc:
UPI000012E473
EMBL:
K00426,
AP009048,
U00096,
D64044
EnsemblGenome:
BAE76745,
b2569
KO:
ecj:JW2553,
eco:b2569
|
| Nucleutide sequences |
EMBL-CDS:
AAA24063.1,
AAC75622.1,
BAA10916.1,
BAE76745.1
EnsemblGenome_TRS:
BAE76745,
AAC75622
|
| Protein sequencees |
EnsemblGenome_PRO:
BAE76745,
AAC75622
RefSeq:
NP_417064.1
|
| Others |
UniRef100:
UniRef100_A7ZQ13
UniRef90:
UniRef90_Q6D217
UniRef50:
UniRef50_Q9A9F4
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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