dapA - 4-hydroxy-tetrahydrodipicolinate synthase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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946952 dapA

基因描述

Type	Description
Definition	4-hydroxy-tetrahydrodipicolinate synthase

研究结论

Date	Results	Publications
2010-01-21 00:00:00	crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from E. coli are presented to 1.9 and 2.0 A, respectively	16041077
2010-01-21 00:00:00	to probe the mechanism of dihydrodipicolinate synthase (DHDPS), inhibition of DHDPS by the substrate analog, beta-hydroxypyruvate was studied; crystal structure of DHDPS complexed with beta-hydroxypyruvate was solved	18787203
2010-01-21 00:00:00	Results suggest that the homotetrameric structure of dihydrodipicolinate synthase reduces dynamic fluctuations present in the dimeric forms and increases specificity for the first substrate, pyruvate.	18556019
2010-01-21 00:00:00	This study investigated the C-terminal domain of E. coli DHDPS by characterising a C-terminal truncated DHDPS (DHDPS-H225*).	19338756
2010-01-21 00:00:00	The dapA promoter is activated by diaminopimelic acid.	15158272

名称对应

Type	IDs
Synonymous	ECK2474
Gene	UniProtKB-ID: DAPA_ECOLI UniprotKB: P0A6L2 UniParc: UPI0000110FD5 EMBL: M33928, U00096, M12844, AP009048, X57402 EnsemblGenome: b2478, BAA16355 KO: ecj:JW2463, eco:b2478
Nucleutide sequences	EMBL-CDS: AAA23665.1, CAA40660.1, AAC75531.1, BAA16355.1 EnsemblGenome_TRS: BAA16355, AAC75531
Protein sequencees	EnsemblGenome_PRO: AAC75531, BAA16355 RefSeq: NP_416973.1
Others	UniRef100: UniRef100_B7M7I1 UniRef90: UniRef90_Q0T239 UniRef50: UniRef50_Q89AY0

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
24561554	The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. Seesandra V Rajagopala , Patricia Sikorski , Ashwani Kumar , Roberto Mosca , James Vlasblom , Roland Arnold , Jonathan Franca-Koh , Suman B Pakala , Sadhna Phanse , Arnaud Ceol , Roman HÃ¤user , Gabriella Siszler , Stefan Wuchty , Andrew Emili , Mohan Babu , Patrick Aloy , Rembert Pieper , Peter Uetz	2014-03-01	-
19505526	Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis. Biochimie Renwick C J Dobson , Matthew A Perugini , Geoffrey B Jameson , Juliet A Gerrard	2009-08-01	dapA
19338756	The C-terminal domain of Escherichia coli dihydrodipicolinate synthase (DHDPS) is essential for maintenance of quaternary structure and efficient catalysis. Biochem. Biophys. Res. Commun. Belinda B B Guo , Sean R A Devenish , Renwick C J Dobson , Andrew C Muscroft-Taylor , Juliet A Gerrard	2009-03-20	dapA
19052357	The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun Sean R A Devenish , Juliet A Gerrard , Geoffrey B Jameson , Renwick C J Dobson	2008-12-01	-
18787203	Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase. Protein Sci Renwick C J Dobson , Michael D W Griffin , Sean R A Devenish , F Grant Pearce , Craig A Hutton , Juliet A Gerrard , Geoffrey B Jameson , Matthew A Perugini	2008-12-01	-
18937497	Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme. Biochemistry F Grant Pearce , Renwick C J Dobson , Anke Weber , Laura A Lane , Margaret G McCammon , Marie A Squire , Matthew A Perugini , Geoffrey B Jameson , Carol V Robinson , Juliet A Gerrard	2008-11-18	dapA
18556019	Evolution of quaternary structure in a homotetrameric enzyme. J. Mol. Biol. Michael D W Griffin , Renwick C J Dobson , F Grant Pearce , Laurence Antonio , Andrew E Whitten , Chu K Liew , Joel P Mackay , Jill Trewhella , Geoffrey B Jameson , Matthew A Perugini , Juliet A Gerrard	2008-07-18	dapA
18304323	Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics Yasushi Ishihama , Thorsten Schmidt , Juri Rappsilber , Matthias Mann , F Ulrich Hartl , Michael J Kerner , Dmitrij Frishman	2008-01-01	-
17187058	Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol. Peng Lu , Christine Vogel , Rong Wang , Xin Yao , Edward M Marcotte	2007-01-01	sspA, talB, dnaK, dnaJ, rpsT, ileS, dapB, carB, ftsZ, murE, aceF, acpP, surA, secA, can, aceE, panB, argF, lpxA, dksA, lpd, erpA, skp, dapD, acnB, tsf, glnH, fabZ, metQ, accA, galM, sodB, panC, pyrH, codA, opgG, pepD, tauB, eno, proC, phoR, thiI, gpmA, leuC, tig, clpP, clpX, lon, adk, htpG, acrB, trpD, apt, ydgH, rplT, purK, ompT, thrC, ybeD, ahpC, purR, glf, serA, miaB, pgm, seqA, rfbB, iscR, asnB, mprA, fldA, fur, sucA, sucB, hisJ, glnS, sucC, sucD, gltA, bioB, pheT, bioD, metK, sdhA, ybiC, tolB, ybiT, ldtB, moeA, gsiB, yliE, ihfA, serS, pflB, serC, aroA, ihfB, rpsA, mukE
16858726	A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis Jean-Paul Lasserre , Emmanuelle Beyne , SlovÃ©nie Pyndiah , Delphine Lapaillerie , StÃ©phane Claverol , Marc Bonneu	2006-08-01	sspA, talB, dnaK, mog, dapB, aceF, acpP, gpt, secA, can, aceE, panB, mrcB, dksA, lpd, skp, dapD, tsf, bamA, fabZ, sodB, panC, yahK, frmA, codA, lacI, pepD, hemB, eno, proC, gpmA, tig, clpP, htpG, dps, acrB, apt, cmtB, rfbA, hybC, ahpC, pgm, rfbB, fur, sucA, osmE, sucC, sucD, gltA, cydA, galE, pheT, metK, moaB, exbB, moeA, rihA, serS, ycaC, pflB, yajG, msbA, rpsA, uxaB, aspC, ompA, hyaB, cbdA, opgH, yniC, deoD, pck, yagU, purB, galU, dhaK, fabD, prs, nfsB, narH, narG, kdsA, ybgI, hns, adhE, sohB, fabI, tpx, pspA, hybO, uspE, narZ, fdnG, gadC, gadB, copA, pyrG, poxB, pntB

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