| Type | Description |
|---|---|
| Definition | chloride:H(+) antiporter ClcA |
| Date | Results | Publications |
|---|---|---|
| 2017-12-02 10:40:00 | Thermodynamic analysis of ion and proton binding shows how the structure of the CLC transporter effects the pH-independent, 2 Cl- to 1 proton binding stoichiometry. The key features are a helix cage, which creates a compact region with a very strong electropositive potential that stabilizes two anions and a single Glutamate that competes with two Cl ions. | 28877486 |
| 2010-01-21 00:00:00 | E203 substitution with Cys and crystal structures of mutants showed that respective Glu is the internal proton-transfer residue that delivers protons from intracellular solution to the protein interior | 19139174 |
| 2010-01-21 00:00:00 | The unitary Cl(-) transport rate, measured in liposomes by both initial-velocity method and a novel Poisson dilution approach, is approximately 4,000 s(-1) for wild-type protein, and the uncoupled mutants transport Cl(-) at similar rates | 17389248 |
| 2010-01-21 00:00:00 | The authors propose that CLC-ec1 operates through an affinity-switch mechanism and that the bases of substrate specificity are conserved in the CLC channels and transporters. | 19898476 |
| 2010-01-21 00:00:00 | Crystallographic study on the ion-binding properties of the ClC selectivity filter in the close homolog from Escherichia coli was presented. | 16341087 |
| Type | IDs |
|---|---|
| Synonymous | ECK0154, eriC, yadQ |
| Gene |
UniProtKB-ID:
CLCA_ECOLI
UniprotKB:
P37019
UniParc:
UPI0000112215
EMBL:
AP009048,
U70214,
U00096
EnsemblGenome:
BAB96732,
b0155
KO:
eco:b0155,
ecj:JW5012
|
| Nucleutide sequences |
EMBL-CDS:
AAB08585.1,
BAB96732.2,
AAC73266.1
EnsemblGenome_TRS:
AAC73266,
BAB96732
|
| Protein sequencees |
EnsemblGenome_PRO:
AAC73266,
BAB96732
RefSeq:
NP_414697.1
|
| Others |
UniRef100:
UniRef100_A7ZHP7
UniRef90:
UniRef90_P58244
UniRef50:
UniRef50_Q9KM62
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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