| Type | Description |
|---|---|
| Definition | heart and neural crest derivatives expressed 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:57:00 | Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects. | 32134193 |
| 2021-01-16 15:54:00 | The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells. | 32444497 |
| 2020-07-18 12:50:00 | Hand2 cardiac subtype diversity (CSD) domain through biochemical analysis of the N terminus. By integrating our RNA-seq and ATAC-seq datasets, we highlight desmosome organization as a hallmark feature of iPM formation. Collectively, our results illuminate Hand2-dependent mechanisms that may guide future efforts to rationally improve iPM formation. | 31116981 |
| 2020-04-18 10:39:00 | FGF1, FGF2, and FGF9 are downstream effectors of HAND2 in endometriosis, enhancing invasive capacity of endometrial fibroblasts. | 30270745 |
| 2020-01-25 10:45:00 | HAND2 loss-of-function mutation co-segregated with familial dilated cardiomyopathy in the carrier family. | 30217752 |
| Type | IDs |
|---|---|
| Synonymous | DHAND2, Hed, Thing2, bHLHa26, dHand |
| Gene |
UniProtKB-ID:
HAND2_HUMAN
UniprotKB:
P61296
UniParc:
UPI0000003FE8,
UPI000058E06B
EMBL:
BC101406,
FJ226608,
AF087940,
AF087941,
CH471056
Ensembl:
ENSG00000164107
KO:
hsa:9464
|
| Nucleutide sequences |
EMBL-CDS:
AAI01407.1,
ACI42790.1,
AAD13185.1,
AAD13186.1,
EAX04749.1
Ensembl_TRS:
ENST00000359562
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000352565
RefSeq:
NP_068808.1
|
| Others |
UniRef100:
UniRef100_P61296
UniRef90:
UniRef90_P61296
UniRef50:
UniRef50_P61296
UniGene:
Hs.388245
CCDS:
CCDS3819.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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