umuC - DNA polymerase V catalytic protein-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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946359 umuC

基因描述

Type	Description
Definition	DNA polymerase V catalytic protein

研究结论

Date	Results	Publications
2019-11-23 10:29:00	We found that the UmuC C-terminal extension has a short region homologous with the RecA N-terminal fragment, itself involved in RecA filament formation. Based on this observation, we proposed a structural model for the UmuC-RecA interaction that rationalizes prior experimental observations.	30916324
2019-04-20 12:22:00	DNA binding and synthesis cannot occur until pol V interacts with a RecA nucleoprotein filament (RecA*) and ATP to form a mutasome complex, pol V Mut = UmuD'2C-RecA-ATP.	30716079
2016-04-30 10:21:00	This work reveals a new level of regulation in the activation of DNA polymerase V. pol V is subject to a novel form of spatial regulation.	26317348
2013-12-21 10:34:00	The UmuC peptide follows the overall disposition of previously characterised structures with respect to the highly conserved glutamine residue.	23822808
2012-12-08 10:59:00	Y11A UmuC mutant has increased UV-sensitivity and reduced UV-mutability due to excessive incorporation of rNTPs during translesion DNA synthesis.	22784977

名称对应

Type	IDs
Synonymous	ECK1172, uvm
Gene	UniProtKB-ID: UMUC_ECOLI UniprotKB: P04152 UniParc: UPI0000137C33 EMBL: M13387, U00096, AP009048, M10107 EnsemblGenome: BAA36031, b1184 KO: ecj:JW1173, eco:b1184
Nucleutide sequences	EMBL-CDS: BAA36031.1, AAA24729.1, AAC74268.1, AAA98074.1 EnsemblGenome_TRS: AAC74268, BAA36031
Protein sequencees	EnsemblGenome_PRO: AAC74268, BAA36031 RefSeq: NP_415702.1
Others	UniRef100: UniRef100_P04152 UniRef90: UniRef90_P04152 UniRef50: UniRef50_P04152

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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全选

Pubmed编号	文献信息	发表日期	相关基因
30916324	New insights into the structures and interactions of bacterial Y-family DNA polymerases. Nucleic Acids Res. KÄstutis Timinskas , Äeslovas Venclovas	2019-05-21	-
30716079	Conformational regulation of Escherichia coli DNA polymerase V by RecA and ATP. PLoS Genet. Malgorzata M Jaszczur , Dan D Vo , Ramunas Stanciauskas , Jeffrey G Bertram , Adhirath Sikand , Michael M Cox , Roger Woodgate , Chi H Mak , Fabien Pinaud , Myron F Goodman	2019-02-01	-
26317348	Regulation of Mutagenic DNA Polymerase V Activation in Space and Time. PLoS Genet Andrew Robinson , John P McDonald , Victor E A Caldas , Meghna Patel , Elizabeth A Wood , Christiaan M Punter , Harshad Ghodke , Michael M Cox , Roger Woodgate , Myron F Goodman , Antoine M van Oijen	2015-08-01	-
25811184	A RecA protein surface required for activation of DNA polymerase V. PLoS Genet. Angela J Gruber , Aysen L Erdem , Grzegorz Sabat , Kiyonobu Karata , Malgorzata M Jaszczur , Dan D Vo , Tayla M Olsen , Roger Woodgate , Myron F Goodman , Michael M Cox	2015-03-01	-
24843026	DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase. Elife Aysen L Erdem , Malgorzata Jaszczur , Jeffrey G Bertram , Roger Woodgate , Michael M Cox , Myron F Goodman	2014-01-01	-
23822808	The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the Î²-clamp processivity factor. BMC Struct. Biol. Atif A Patoli , Jody A Winter , Karen A Bunting	2013-01-01	umuC
22784977	Escherichia coli UmuC active site mutants: effects on translesion DNA synthesis, mutagenesis and cell survival. DNA Repair (Amst.) Wojciech Kuban , Alexandra Vaisman , John P McDonald , Kiyonobu Karata , Wei Yang , Myron F Goodman , Roger Woodgate	2012-09-01	-
22422840	Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity. Nucleic Acids Res. Alexandra Vaisman , Wojciech Kuban , John P McDonald , Kiyonobu Karata , Wei Yang , Myron F Goodman , Roger Woodgate	2012-07-01	umuC
22001238	Role of damage-specific DNA polymerases in M13 phage mutagenesis induced by a major lipid peroxidation product trans-4-hydroxy-2-nonenal. Mutat. Res. Beata Janowska , Dagmara Kurpios-Piec , Paulina Prorok , Grzegorz Szparecki , Marek Komisarski , PaweÅ Kowalczyk , Celina Janion , Barbara Tudek	2012-01-03	polB, dinB, umuC
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-

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