| Type | Description |
|---|---|
| Definition | ATP-independent periplasmic chaperone |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 11:48:00 | We revealed an important protein-folding defect in the DeltaelyC mutant and showed that overproduction of the periplasmic chaperone DsbG or Spy was sufficient to correct the protein-folding defect and restore peptidoglycan biosynthesis. | 30012727 |
| 2019-04-13 11:41:00 | Increasing the ionic strength inhibits ATP-independent periplasmic chaperone, Spy activity in vivo, strongly suggesting that electrostatic forces are important for chaperone function in vivo. The function of the super Spy variant Q100L is also salt-sensitive, despite its increased hydrophobicity, further emphasizing the importance of electrostatic interactions in Spy function. | 29870331 |
| 2017-06-10 10:29:00 | Visualizing of Spy chaperone-assisted Im7 protein folding has been reported. | 27239796 |
| 2017-01-14 11:39:00 | Experimental results on Spy-Im7 interactions were used to construct a model for how this chaperone interacts with its clients. It appears that Spy binds to and releases client proteins in a regulated fashion that uses client protein folding as its own cue for release. | 27293188 |
| 2016-05-14 10:58:00 | Spy rapidly associates with its substrate, immunity protein 7 (Im7), thereby eliminating Im7's potential for aggregation. | 26619265 |
| Type | IDs |
|---|---|
| Synonymous | ECK1741 |
| Gene |
UniProtKB-ID:
SPY_ECOLI
UniprotKB:
P77754
UniParc:
UPI0000135E9F
EMBL:
U00096,
AP009048,
Y07714
EnsemblGenome:
b1743,
BAA15531
KO:
eco:b1743,
ecj:JW1732
|
| Nucleutide sequences |
EMBL-CDS:
BAA15531.1,
AAC74813.1,
CAA68986.1
EnsemblGenome_TRS:
AAC74813,
BAA15531
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA15531,
AAC74813
RefSeq:
NP_416257.1
|
| Others |
UniRef100:
UniRef100_P77754
UniRef90:
UniRef90_P77754
UniRef50:
UniRef50_P77754
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
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